Steroid Hormones, Endometrial Gene Regulation and the Sp1 Family of Proteins

Steroid Hormones, Endometrial Gene Regulation and the Sp1 Family of Proteins
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类固醇激素、子宫内膜基因调控和 Sp1 蛋白家族

DOI:
10.1177/107155760200900602
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发表时间:
2002
期刊:
Journal of the Society for Gynecologic Investigation
影响因子:
--
通讯作者:
C. Lockwood
C. Lockwood
中科院分区:
--
文献类型:
--
作者:
G. Krikun;C. Lockwood

文献摘要

参考文献

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Endometrial gene expression can be regulated exquisitely by cyclical changes in ovarian steroid concentration. Although hormonal induction of many of these genes occurs through classical steroid response elements, other endometrial genes respond to steroids at the transcriptional level but do not contain steroid response elements. A family of transcription factors, namely the Sp1 family, has now been implicated as important mediators of steroid hormone action in the endometrium during the periimplantation and postimplantation periods. This review summarizes the current literature regarding the role of the Sp1 protein family in regulating the response to steroid hormones of genes for tissue factor, plasminogen activator inhibitor-1, insulin-like growth factor binding protein-1, uteroglobin, and uteroferrin in the endometrium.
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DOI: --
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期刊: The Journal of biological chemistry
影响因子: --
作者:
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