Identification and characterization of a widely expressed phosphate transporter retrovirus receptor family
Identification and characterization of a widely expressed phosphate transporter retrovirus receptor family
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DOI：
10.1038/ki.1996.135
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发表时间：
1996-04-01
影响因子：
19.6
通讯作者：
Kabat, D
中科院分区：
文献类型：
--
作者：
Kavanaugh, MP;Kabat, D
长臂猿白血病病毒(Glvr-1；[1])和大鼠两性病毒(Ram-1；[2])的细胞表面受体最近被证明作为钠依赖的磷酸盐转运体发挥正常的细胞功能[3，4]。这两个转运蛋白分别是CANED PIT-1和PIT-2，氨基酸序列有59%的同源性，是有别于肾型和II型NaPI钠依赖的磷酸转运蛋白的基因家族成员。PIT-1和PIT-2广泛分布于肾、脑、心脏、肝脏、肌肉和骨髓等多种组织中。这两种转运蛋白的表达都因缺磷而增加。这些分子独特的结构和功能特性使它们成为一个新的磷酸盐转运蛋白家族的成员，该家族可能在多种细胞类型的磷酸盐吸收中发挥重要作用。
The cell-surface receptors for gibbon ape leukemia virus (Glvr-1; [1]) and rat amphotropic virus (Ram-1; [2]) were recently demonstrated to serve normal cellular functions as sodium-dependent phosphate transporters [3, 4]. These transporters, caned PiT-1 and PiT-2, respectively, are approximately 59% identical in amino acid sequence and are members of a gene family distinct from the renal type I and type II NaPi sodium-dependent phosphate transporters. Both PiT-1 and PiT-2 are widely distributed in many tissues including kidney, brain, heart, liver, muscle, and bone marrow. Expression of both transporters is increased by phosphate deprivation. The distinct structural and functional properties of these molecules establishes them as members of a new family of phosphate transporters which may play a major role in phosphate uptake in a wide variety of cell types.