Humoral immunity links Candida albicans infection and celiac disease.
Humoral immunity links Candida albicans infection and celiac disease.
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DOI：
10.1371/journal.pone.0121776
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Poulain D
中科院分区：
文献类型：
--
作者：
Corouge M;Loridant S;Fradin C;Salleron J;Damiens S;Moragues MD;Souplet V;Jouault T;Robert R;Dubucquoi S;Sendid B;Colombel JF;Poulain D
The protein Hwp1, expressed on the pathogenic phase of Candida albicans, presents sequence analogy with the gluten protein gliadin and is also a substrate for transglutaminase. This had led to the suggestion that C. albicans infection (CI) may be a triggering factor for Celiac disease (CeD) onset. We investigated cross-immune reactivity between CeD and CI. Serum IgG levels against recombinant Hwp1 and serological markers of CeD were measured in 87 CeD patients, 41 CI patients, and 98 healthy controls (HC). IgA and IgG were also measured in 20 individuals from each of these groups using microchips sensitized with 38 peptides designed from the N-terminal of Hwp1. CI and CeD patients had higher levels of anti-Hwp1 (p=0.0005 and p=0.004) and anti-gliadin (p=0.002 and p=0.0009) antibodies than HC but there was no significant difference between CeD and CI patients. CeD and CI patients had higher levels of anti-transglutaminase IgA than HC (p=0.0001 and p=0.0039). During CI, the increase in anti-Hwp1 paralleled the increase in anti-gliadin antibodies. Microchip analysis showed that CeD patients were more reactive against some Hwp1 peptides than CI patients, and that some deamidated peptides were more reactive than their native analogs. Binding of IgG from CeD patients to Hwp1 peptides was inhibited by γIII gliadin peptides. Humoral cross-reactivity between Hwp1 and gliadin was observed during CeD and CI. Increased reactivity to Hwp1 deamidated peptide suggests that transglutaminase is involved in this interplay. These results support the hypothesis that CI may trigger CeD onset in genetically-susceptible individuals.
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影响因子：
6.7
作者：
Maddur MS;Vani J;Lacroix-Desmazes S;Kaveri S;Bayry J
通讯作者：
Bayry J
影响因子：
1.5
作者：
Garcia, YH;Díez, SG;Oliva, NP
通讯作者：
Oliva, NP
DOI：
10.1126/science.1221789
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iliev ID;Funari VA;Taylor KD;Nguyen Q;Reyes CN;Strom SP;Brown J;Becker CA;Fleshner PR;Dubinsky M;Rotter JI;Wang HL;McGovern DP;Brown GD;Underhill DM
通讯作者：
Underhill DM
影响因子：
4.4
作者：
Hodrea, Judit;Demeny, Mate A.;Fesus, Laszlo
通讯作者：
Fesus, Laszlo
影响因子：
3.5
作者：
Facchiano, Angelo;Facchiano, Francesco
通讯作者：
Facchiano, Francesco