A NEW VIEW OF PROSTAGLANDIN-E REGULATION OF THE IMMUNE-RESPONSE
A NEW VIEW OF PROSTAGLANDIN-E REGULATION OF THE IMMUNE-RESPONSE
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DOI：
10.1016/0167-5699(91)90064-z
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发表时间：
1991-10-01
期刊：
影响因子：
--
通讯作者：
ROPER, RL
中科院分区：
文献类型：
--
作者：
PHIPPS, RP;STEIN, SH;ROPER, RL
前列腺素，特别是E系列前列腺素，被广泛认为是真核细胞的免疫抑制产物，可以下调B细胞和T细胞功能的许多方面。在这篇文章中，Richard Phips及其同事提出了E系列前列腺素的一个不同的概念，基于最近的证据支持前列腺素作为免疫球蛋白类转换的增强剂以及选择的细胞因子和细胞因子受体的合成的作用。
Prostaglandins, particularly those of the E series, are widely regarded as immunosuppressive products of eukaryotic cells that can downregulate many aspects of B- and T-cell function. In this article, Richard Phipps and colleagues present a different concept of E series prostaglandins, based on recent evidence supporting a role for prostaglandins as potentiators of immunoglobulin class switching and of the synthesis of selected cytokines and cytokine receptors.