Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp.
Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp.
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内生木霉属中含脯氨酸环五肽的分离和结构解析。
DOI：
10.1021/np100909y
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发表时间：
2011-05-01
影响因子：
5.1
通讯作者：
Liu, Hongwei
中科院分区：
文献类型：
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作者：
Wu, Wen;Dai, Huanqin;Liu, Hongwei
两个新的循环五肽(1和2)和已知blazein (3), ganodesterone(4),麦角固醇(5),cerevisterol (6), 24-methylcholesta-4, 6、8 (14),22-tetraen-3-one(7), 5、8-epidioxyergosta-6, 22-dien-3-ol (8), 16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic酸(9),16-hydroxy isopimar-7-en-19-oic酸(10)被隔绝的粗提取液endolichenic Xylaria sp。1和2的结构主要由NMR和MS方法阐明。用Marfey方法对它们的酸水解产物进行了绝对构型的确定。对化合物1 ~ 10的抗真菌活性和协同抗真菌活性进行了评价。化合物1与0.004 μ g/mL酮康唑对白色念珠菌SC5314具有协同抗真菌活性。
Two new cyclic pentapeptides (1 and 2) and the known blazein (3), ganodesterone (4), ergosterin (5), cerevisterol (6), 24-methylcholesta-4,6,8(14),22-tetraen-3-one (7), 5,8-epidioxyergosta-6,22-dien-3-ol (8), 16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic acid (9), and 16-hydroxy isopimar-7-en-19-oic acid (10) have been isolated from the crude extract of an endolichenic Xylaria sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 2 were assigned using Marfey's method on their acid hydrolysate. Compounds 1-10 were evaluated for activity against fungi and for synergistic antifungal activity. Compound 1 showed synergistic antifungal activity against Candida albicans SC5314 with 0.004 mu g/mL ketoconazole.