Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections - United States
Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections - United States
复制标题
DOI：
10.15585/mmwr.mm6809e1
复制
发表时间：
2019-03-08
影响因子：
33.9
通讯作者：
Cardo, Denise
中科院分区：
文献类型：
--
作者：
Kourtis, Athena P.;Hatfield, Kelly;Cardo, Denise
简介：金黄色葡萄球菌是卫生保健机构和社区中最常见的病原体之一，可引起侵入性感染、败血症和死亡。尽管在预防耐甲氧西林沙门氏菌方面取得了进展.因此，鉴于卫生保健环境中的金黄色葡萄球菌（MRSA）感染，需要在卫生保健和社区环境中评估该问题。此外，甲氧西林敏感的S。金黄色葡萄球菌（MSSA）感染在国家一级没有得到很好的描述。新兴感染项目（EIP）MRSA人群监测数据（2005-2016年）以及Premier和Caner电子健康记录数据库（2012-2017年）进行了分析，以描述医院发病和社区发病的MRSA和MSSA血流感染的发生率趋势，并估计链球菌的总体发生率。金黄色葡萄球菌血流感染在美国和相关的住院死亡率。结果：在2017年，估计有119，247 S。金黄色葡萄球菌血流感染导致19，832人死亡。在2005-2012年期间，医院发生的MRSA血流感染率每年下降17.1%，但在2013-2016年期间下降放缓。2005-2016年期间，社区发病的MRSA下降不太明显（每年6.90），主要与医疗保健相关感染的下降有关。医院发病的MSSA没有显著变化（p = 0.11），社区发病的MSSA感染略有增加（每年3.9%，p
Introduction: Staphylococcus aureus is one of the most common pathogens in health care facilities and in the community, and can cause invasive infections, sepsis, and death. Despite progress in preventing methicillin - resistant S. aureus (MRSA) infections in health care settings, assessment of the problem in both health care and community settings is needed. Further, the epidemiology of methicillin-susceptible S. aureus (MSSA) infections is not well described at the national level.Methods: Data from the Emerging Infections Program (EIP) MRSA population surveillance (2005-2016) and from the Premier and Caner Electronic Health Record databases (2012-2017) were analyzed to describe trends in incidence of hospital-onset and community-onset MRSA and MSSA bloodstream infections and to estimate the overall incidence of S. aureus bloodstream infections in the United States and associated in-hospital mortality.Results: In 2017, an estimated 119,247 S. aureus bloodstream infections with 19,832 associated deaths occurred. During; 2005-2012 rates of hospital-onset MRSA bloodstream infection decreased by 17.1% annually, but the decline slowed during 2013-2016. Community-onset MRSA declined less markedly (6.9 0 ) annually during 2005-2016), mostly related to declines in health care-associated infections. Hospital onset MSSA has not significantly changed (p = 0.11) , and community-onset MSSA infections have slightly increased (3.9% per year, p