Cortical networks for speech motor control in unilateral vocal fold paralysis.
Cortical networks for speech motor control in unilateral vocal fold paralysis.
复制标题
单侧声带麻痹言语运动控制的皮质网络。
DOI：
10.1002/lary.27730
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Cheung,StevenW
中科院分区：
文献类型：
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作者：
Naunheim,MollyL;Yung,KatherineC;Schneider,SarahL;Henderson-Sabes,Jennifer;Kothare,Hardik;Hinkley,LeightonB;Mizuiri,Danielle;Klein,DavidJ;Houde,JohnF;Nagarajan,SrikantanS;Cheung,StevenW
Objectives evaluate brain networks for motor control of voice production in patients with treated unilateral vocal fold paralysis（UVFP）.Study DesignCross-sectional comparison.MethodsNine UVFP patients treated by type I thyroplasty，and 11 control subjects were compared with using magnetoencephalography imaging to measure beta band（12-30 Hz）neural occurrences during voice production with perturbation of pitch feedback.β波段功率相对于基线的差异进行了分析，以确定皮质区的异常活动在400毫秒的扰动期间和125毫秒以外，共525 ms. Results-whole-brain任务诱导的β波段激活模式是定性相似的治疗UVFP患者和健康对照。中央声乐运动控制的可塑性UVFP内表达的健康对照组中确定的中央人类通信网络的组成部分。治疗的UVFP患者表现出统计学上显著的增强（P< 0.05）在音高扰动开始后左侧听觉皮层525 ms、左侧运动前皮层225 ms和左右额叶皮层525 ms的β带活动。结论本研究进一步证实了喉外周运动障碍可以影响参与听觉反馈处理的中枢皮层网络，发声运动控制和声音自我判断未来的研究，解剖结构性皮层网络之间的功能关系，可以揭示中枢贡献的神经生理基础，在UVFP的声音产生障碍。这些新的见解将激励创新的治疗方法，以改善语音产生，减少临床医生和患者之间的语音质量判断偏差。证据水平3b喉镜，129：2125-2130，2019
ObjectiveTo evaluate brain networks for motor control of voice production in patients with treated unilateral vocal fold paralysis (UVFP).Study DesignCross‐sectional comparison.MethodsNine UVFP patients treated by type I thyroplasty, and 11 control subjects were compared using magnetoencephalographic imaging to measure beta band (12–30 Hz) neural oscillations during voice production with perturbation of pitch feedback. Differences in beta band power relative to baseline were analyzed to identify cortical areas with abnormal activity within the 400 ms perturbation period and 125 ms beyond, for a total of 525 ms.ResultsWhole‐brain task‐induced beta band activation patterns were qualitatively similar in both treated UVFP patients and healthy controls. Central vocal motor control plasticity in UVFP was expressed within constitutive components of central human communication networks identified in healthy controls. Treated UVFP patients exhibited statistically significant enhancement (P< 0.05) in beta band activity following pitch perturbation onset in left auditory cortex to 525 ms, left premotor cortex to 225 ms, and left and right frontal cortex to 525 ms.ConclusionThis study further corroborates that a peripheral motor impairment of the larynx can affect central cortical networks engaged in auditory feedback processing, vocal motor control, and judgment of voice‐as‐self. Future research to dissect functional relationships among constitutive cortical networks could reveal neurophysiological bases of central contributions to voice production impairment in UVFP. Those novel insights would motivate innovative treatments to improve voice production and reduce misalignment of voice‐quality judgment between clinicians and patients.Level of Evidence3bLaryngoscope, 129:2125–2130, 2019