Binding of hepatitis C virus to CD81
Binding of hepatitis C virus to CD81
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DOI：
10.1126/science.282.5390.938
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发表时间：
1998-10-30
期刊：
影响因子：
56.9
通讯作者：
Abrignani, S
中科院分区：
文献类型：
--
作者：
Pileri, P;Uematsu, Y;Abrignani, S
慢性丙型肝炎病毒(丙型肝炎病毒)感染发生在大约3%的世界人口中，是肝病的主要原因。丙型肝炎病毒感染也与冷球蛋白血症有关，冷球蛋白血症是一种B淋巴细胞增生性疾病。病毒的趋向性是有争议的，细胞进入的机制仍不清楚。丙型肝炎病毒包膜蛋白E2与人CD81结合，CD81是一种在包括肝细胞和B淋巴细胞在内的多种细胞类型上表达的Tetraspanin。E2的结合被映射到CD81的主胞外环。含有这个环的重组分子结合丙型肝炎病毒，体内中和丙型肝炎病毒感染的抗体在体外抑制病毒与CD81的结合。
Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population and is a major cause of liver disease. HCV infection is also associated with cryoglobulinemia, a B Lymphocyte proliferative disorder. Virus tropism is controversial, and the mechanisms of cell entry remain unknown. The HCV envelope protein E2 binds human CD81,a tetraspanin expressed on various cell types including hepatocytes and B Lymphocytes. Binding of E2 was mapped to the major extracellular Loop of CD81. Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.