Modular domains of focal adhesion-associated proteins.
Modular domains of focal adhesion-associated proteins.
复制标题
粘着斑相关蛋白的模块化结构域。
DOI：
10.1007/978-3-642-80481-6_6
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发表时间：
1998
影响因子：
--
通讯作者：
Parsons,JT
中科院分区：
文献类型：
--
作者：
Taylor,JM;Richardson,A;Parsons,JT
Attachment of cells to the extracellular matrix is mediated by structures called “focal adhesions.” Focal adhesions can be readily visualized by reflection contrast microscopy in cells grown in culture either on plastic or a defined extracellular matrix (ECM; e.g., fibronectin, collagen), appearing as spear tip-like structures connecting the extracellular matrix with the ventral plasma membrane (Jockuschet al. 1995). The cytoplasmic face of such structures is decorated with the termini of numerous actin stress filaments, indicating a direct linkage with the actin cytoskeletal network. Focal adhesions not only provide the cell with a point of adhesive contact with the extracellular matrix, but also function to mediate signals that regulate cell growth, migration and apoptosis (Burridgeand Chrzanowska-Wodnicka1996; Hynes1992; Jockuschet al. 1995). The regulated assembly of focal adhesions at the leading edge of the cell is a central step in cell migration and more specialized processes such as axonal growth (Hynes1992; Lauffenbergerand Horwitz1996). Loss of adhesion to the ECM can lead to cell cycle arrest or in some cells the induction of programmed cell death (Rouslahtiand Reed1994). Thus, adhesive interactions with the ECM play a critical role in regulating a variety of intracellular signaling pathways.
