The decrease of particle-induced osteolysis after a single dose of bisphosphonate
The decrease of particle-induced osteolysis after a single dose of bisphosphonate
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DOI：
10.1016/j.biomaterials.2004.06.010
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发表时间：
2005-05-01
期刊：
影响因子：
14
通讯作者：
Löer, F
中科院分区：
文献类型：
--
作者：
von Knoch, M;Wedemeyer, C;Löer, F
关节置换术中植入物失效的最常见原因是颗粒诱导的骨质溶解导致的无菌性松动。已证明双膦酸盐每日给药可有效对抗颗粒诱导的骨质溶解。我们利用C57 BL/J6小鼠颅骨骨溶解模型，研究了皮下注射更有效的第三代双膦酸盐对颗粒诱导的骨溶解的影响。使用姬姆萨染色测量中线缝线内的骨吸收。使用了28只小鼠。每组七个。7只动物在手术后直接接受单剂量唑来膦酸（ZA）治疗，7只动物在手术后4天接受治疗。采用单因素方差分析和Student t检验进行统计学分析，植入颗粒的动物骨吸收为0.26+/-0.09 mm（2）。术后直接进行颗粒植入和ZA治疗的动物为0.14+/-0.05 mm（2）（p = 0.0047），术后第4天进行颗粒植入和ZA治疗的动物为0.15+/-0.05 mm（2）（p = 0.006）。第三代双膦酸盐这一重要的新发现有很大的希望，因为与重复应用双膦酸盐相比，颗粒诱导的骨质溶解的单次给药治疗可能会减少副作用。(C)2004 Elsevier Ltd.保留所有权利。
The most common cause of implant failure in joint replacement is aseptic loosening due to particle-induced osteolysis. Bisphosphonates have been shown to be effective against particle-induced osteolysis when administered daily. We investigated the effect of a single subcutaneous dose of a more potent third generation bisphosphonate on particle-induced osteolysis.We utilized the murine calvaria osteolysis model in C57BL/J6 mice. Bone resorption was measured as resorption within the midline suture using Giemsa staining. Twenty-eight mice were used. seven per group. Seven animals were treated with a single dose of zoledronic acid (ZA) directly after surgery and seven animals were treated four days postoperatively. For statistical analysis one-way ANOVA and a Student's t-test were used.Bone resorption was 0.26+/-0.09 mm(2) in animals with particle implantation. 0.14+/-0.05 mm(2) in animals with particle implantation and ZA treatment directly after surgery (p = 0.0047), and 0.15+/-0.05 mm(2) in animals with particle implantation and ZA treatment on the fourth postoperative day (p = 0.006).In conclusion, particle-induced bone resorption was markedly decreased by a single s.c. dose of a third generation bisphosphonate. This important new finding holds great promise, because single dose treatment of particle-induced osteolysis may reduce side effects compared to repeated application of bisphosphonates. (C) 2004 Elsevier Ltd. All rights reserved.