Influenza-Omics and the Host Response: Recent Advances and Future Prospects.
Influenza-Omics and the Host Response: Recent Advances and Future Prospects.
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DOI：
10.3390/pathogens6020025
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发表时间：
2017-06-10
期刊：
影响因子：
--
通讯作者：
Waters KM
中科院分区：
文献类型：
--
作者：
Powell JD;Waters KM
甲型流感病毒(IAV)不断进化，并有能力导致全球大流行。由于IAV是一种持续的威胁，识别新的治疗方法和宿主先天性免疫因子对IAV的发病机制具有相当大的兴趣。本文综述了蛋白质组和转录组水平上有关全球宿主对流感感染的反应的相关文献。综述了各种组学感染系统，包括但不限于雪貂、小鼠、猪，甚至人类的受控感染。讨论的重点是与流感组学感染结果有关的最新进展、仍然存在的挑战和知识差距。
Influenza A viruses (IAV) continually evolve and have the capacity to cause global pandemics. Because IAV represents an ongoing threat, identifying novel therapies and host innate immune factors that contribute to IAV pathogenesis is of considerable interest. This review summarizes the relevant literature as it relates to global host responses to influenza infection at both the proteome and transcriptome level. The various-omics infection systems that include but are not limited to ferrets, mice, pigs, and even the controlled infection of humans are reviewed. Discussion focuses on recent advances, remaining challenges, and knowledge gaps as it relates to influenza-omics infection outcomes.