Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: Event-related fMRI evidence
Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: Event-related fMRI evidence
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DOI：
10.1176/appi.ajp.163.6.1033
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发表时间：
2006-06-01
影响因子：
17.7
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Tamm, Leanne;Menon, Vinod;Reiss, Allan L.
目的：注意力缺陷多动障碍（ADHD）患者的定向注意力（将注意力分配和引导到显著刺激的能力）受损。这种结构通常通过目标检测或古怪任务进行评估，ADHD患者在这些任务中表现不佳。然而，迄今为止，尚未确定ADHD患者目标检测功能障碍的具体脑结构或神经机制。作者的目标是调查神经相关的目标检测功能障碍在ADHD使用事件相关fMRI。方法：行为和大脑激活数据收集，而受试者进行视觉古怪的任务。参与者包括14名右撇子男性青少年与ADHD（组合型）和12个典型的发展年龄和handedness匹配的男性comparison subjects.Results：个人与ADHD的委员会比比较科目的错误显着。此外，相对于比较科目，ADHD的个人表现出显着较少的激活，在双侧顶叶（包括上级顶叶回和缘上回和角回的顶叶下叶），右楔前叶，和thalachus.Conclusions：ADHD的青少年表现出显着的损害，在他们的能力，直接和分配注意力资源。这些困难与顶叶注意力系统中的显著畸变有关，顶叶注意力系统在注意力转移和检测特定或突出目标中起着重要作用。因此，顶叶注意系统功能障碍可能在ADHD的行为表型中起重要作用。
Objective: Directed attention, the ability to allocate and direct attention toward a salient stimulus, is impaired in attention deficit hyperactivity disorder (ADHD). This construct is often assessed with target detection or oddball tasks, and individuals with ADHD perform poorly on such tasks. However, to date, the specific brain structures or neural mechanisms underlying target detection dysfunction in individuals with ADHD have not been identified. The authors' goal was to investigate neural correlates of target detection dysfunction in ADHD using event-related fMRI.Method: Behavioral and brain activation data were collected while subjects performed a visual oddball task. Participants included 14 right-handed male adolescents with ADHD (combined type) and 12 typically developing age-and handedness-matched male comparison subjects.Results: Individuals with ADHD made significantly more errors of commission than comparison subjects. Further, relative to comparison subjects, individuals with ADHD showed significantly less activation in the bilateral parietal lobes (including the superior parietal gyrus and supramarginal and angular gyri of the inferior parietal lobe), right precuneus, and thalamus.Conclusions: Adolescents with ADHD demonstrated significant impairments in their ability to direct and allocate attentional resources. These difficulties were associated with significant aberrations in the parietal attentional system, which is known to play a significant role in attention shifting and detecting specific or salient targets. Thus, dysfunction in the parietal attentional system may play a significant role in the behavioral phenotype of ADHD.