Multiparametric imaging with heterogeneous radiofrequency fields.
Multiparametric imaging with heterogeneous radiofrequency fields.
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DOI：
10.1038/ncomms12445
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发表时间：
2016-08-16
影响因子：
16.6
通讯作者：
Sodickson DK
中科院分区：
文献类型：
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作者：
Cloos MA;Knoll F;Zhao T;Block KT;Bruno M;Wiggins GC;Sodickson DK
磁共振成像（MRI）已成为一种无与伦比的医学诊断技术，能够非侵入性地绘制组织解剖学和生理学。精心设计MRI测量以控制样品中的实验条件。但是，残留的射频（RF）场不均匀性通常是不可避免的，导致伪影降低了图像的诊断和科学价值。在这里，我们表明，可以通过故意将自由变化的异质RF场与磁共振指纹指纹的数据刷新过程交织在一起来消除这些伪像。基于模拟进行的观察在7 tesla（t）的实验中得到了证实，并在3T处的骨科植入物附近使用体内测量结果来说明这种新范式的临床意义。这些结果表明，可以使用异质的RF场进行定量的多参数成像，并使MRI摆脱传统的控制RF场均匀性的斗争。
磁共振指纹（MRF）需要一个均匀的B1 +射频场。在这里，作者提出了插头-n-play MRF，该技术可以使用异质B1 +场进行多参数成像，并在存在由金属骨科植入物引起的RF失真的情况下演示其效用。
Magnetic resonance imaging (MRI) has become an unrivalled medical diagnostic technique able to map tissue anatomy and physiology non-invasively. MRI measurements are meticulously engineered to control experimental conditions across the sample. However, residual radiofrequency (RF) field inhomogeneities are often unavoidable, leading to artefacts that degrade the diagnostic and scientific value of the images. Here we show that, paradoxically, these artefacts can be eliminated by deliberately interweaving freely varying heterogeneous RF fields into a magnetic resonance fingerprinting data-acquisition process. Observations made based on simulations are experimentally confirmed at 7 Tesla (T), and the clinical implications of this new paradigm are illustrated with in vivo measurements near an orthopaedic implant at 3T. These results show that it is possible to perform quantitative multiparametric imaging with heterogeneous RF fields, and to liberate MRI from the traditional struggle for control over the RF field uniformity. Magnetic resonance fingerprinting (MRF) requires a uniform B1 + radiofrequency field. Here the authors present plug-n-play MRF, a technique that enables multiparametric imaging with heterogeneous B1 + fields, and demonstrate its utility in the presence of RF distortion caused by a metallic orthopaedic implant.