Hijacking of the AP-1 Signaling Pathway during Development of ATL.
Hijacking of the AP-1 Signaling Pathway during Development of ATL.
复制标题
ATL开发过程中AP-1信号通路的劫持。
DOI：
10.3389/fmicb.2017.02686
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发表时间：
2017
影响因子：
5.2
通讯作者：
Peloponese JM Jr
中科院分区：
文献类型：
--
作者：
Gazon H;Barbeau B;Mesnard JM;Peloponese JM Jr
人类 T 细胞白血病病毒 1 型 (HTLV-1) 是一种称为成人 T 细胞白血病 (ATL) 的致命恶性肿瘤的病原体。解决该疾病病理学的一种方法是利用分子方法进行研究。除了分析 ATL 相关信号通路外，了解重要且相关的转录因子的调节也能让研究人员实现这一基本目标。 HTLV-1 编码两种癌蛋白：Tax 和 HTLV-1 碱性亮氨酸拉链因子，它们在细胞转化和宿主免疫反应的激活中发挥重要作用。自从 Jun 和 Fos 基因家族的第一个代表性成员被克隆并被证明是病毒癌基因的细胞同源物以来，激活蛋白 1 (AP-1) 转录因子就与癌症和肿瘤转化相关。 AP-1 是一种二聚体转录因子，由属于 Jun（c-Jun、JunB 和 JunD）、Fos（c-Fos、FosB、Fra1 和 Fra2）的蛋白和激活转录因子蛋白家族组成。 AP-1转录因子家族被不同的刺激（例如炎症细胞因子、应激诱导物或病原体）激活，导致先天性和适应性免疫。 AP-1 还参与多种细胞事件，包括分化、增殖、存活和凋亡。 AP-1 转录因子表达失调与多种淋巴瘤有关，例如经典霍奇金淋巴瘤、间变性大细胞淋巴瘤、弥漫性大 B 细胞淋巴瘤和成人 T 细胞白血病。在这里，我们回顾了当前 AP-1 通路解除管制背后的想法及其对 HTLV 诱导的细胞转化的贡献。
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies on conducting research with a molecular approach. In addition to the analysis of ATL-relevant signaling pathways, understanding the regulation of important and relevant transcription factors allows researchers to reach this fundamental objective. HTLV-1 encodes for two oncoproteins, Tax and HTLV-1 basic leucine-zipper factor, which play significant roles in the cellular transformation and the activation of the host’s immune responses. Activating protein-1 (AP-1) transcription factor has been linked to cancer and neoplastic transformation ever since the first representative members of the Jun and Fos gene family were cloned and shown to be cellular homologs of viral oncogenes. AP-1 is a dimeric transcription factor composed of proteins belonging to the Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), and activating transcription factor protein families. Activation of AP-1 transcription factor family by different stimuli, such as inflammatory cytokines, stress inducers, or pathogens, results in innate and adaptive immunity. AP-1 is also involved in various cellular events including differentiation, proliferation, survival, and apoptosis. Deregulated expression of AP-1 transcription factors is implicated in various lymphomas such as classical Hodgkin lymphomas, anaplastic large cell lymphomas, diffuse large B-cell lymphomas, and adult T-cell leukemia. Here, we review the current thinking behind deregulation of the AP-1 pathway and its contribution to HTLV-induced cellular transformation.
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影响因子：
20.3
作者：
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通讯作者：
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影响因子：
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作者：
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Mesnard, Jean-Michel
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通讯作者：
Zatloukal, K