PLASMA AVP, NEUROPHYSIN, RENIN-ACTIVITY, AND ALDOSTERONE DURING SUBMAXIMAL EXERCISE PERFORMED UNTIL EXHAUSTION IN TRAINED AND UNTRAINED MEN
PLASMA AVP, NEUROPHYSIN, RENIN-ACTIVITY, AND ALDOSTERONE DURING SUBMAXIMAL EXERCISE PERFORMED UNTIL EXHAUSTION IN TRAINED AND UNTRAINED MEN
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DOI：
10.1007/bf00421092
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发表时间：
1980-01-01
影响因子：
3
通讯作者：
GHARIB, C
中科院分区：
文献类型：
--
作者：
MELIN, B;ECLACHE, JP;GHARIB, C
对14名男性受试者进行了高强度肌肉运动(占最大摄氧量的80%)对血浆电解质和水平衡激素反应的影响。根据他们的最大摄氧量和运动到力竭的持续时间分为3组：训练组(I组)、训练组(II组)和未训练组(III组)。测定肺气体交换、心率、直肠和皮肤温度、体重、红细胞压积、血浆和尿钠、钾浓度。力竭后所有受试者的直肠温度均显著升高。在训练有素的受试者中，红细胞压积的变化最小，体重下降最大。3组患者运动后血浆醛固酮、肾素活性(PRA)、加压素(AVP)和神经降压素(NP)均有非常显著的升高，其中PRA升高4.5倍(P<；0.01)，醛固酮升高13倍(P<；0.05)，NP升高2.6倍(P<；0.05)，AVP升高4.8倍(P<；0.05)。PRA的变化与血浆醛固酮的变化或与血浆Na、K的变化无相关性。在尿液水平，运动后游离H2O清除量趋于正值。显然，这种运动会极大地提高血浆中涉及电解质和水平衡的荷尔蒙水平。在训练有素的受试者中，虽然红细胞压积的增加最小，但汗液流失量最高；这表明H2O从血管外腔更有效地被转移。
The effect of intense muscular work (80% of maximal O2 uptake) on responses of plasma hormones involved in electrolyte and H2O balance were measured in 14 male subjects. They were divided into 3 groups according to their maximal O2 uptake and the duration of exercise performed until exhaustion: well trained subjects (group I), trained subjects (group II) and untrained subjects (group III). Pulmonary gas exchange, heart rate, rectal and skin temperature and weight loss were measured as well as hematocrit and plasma and urine Na and K concentrations. Rectal temperature increased significantly in all subjects after exhaustion. The variation of hematocrit was smallest and the weight loss greatest in the well-trained subjects. Plasma aldosterone, renin activity (PRA), vasopressin (AVP) and neurophysin (Np) displayed highly significant increases after exercise in all 3 groups: PRA was increased 4.5 times (P < 0.01), aldosterone 13 times (P < 0.05),, Np 2.6 times (P < 0.05) and AVP 4.8 times (P < 0.05). There was no correlation between the changes in PRA and those in plasma aldosterone, or between aldosterone and plasma Na or K. At the urinary level, free H2O clearance tends to become positive after exercise. Evidently this kind of exercise produces a highly significant increase in plasma levels of the hormones involved in electrolyte and H2O balance. It is among the well-trained subjects that sweat loss is highest though the hematocrit increase is the smallest; this suggests that H2O is shifted more efficiently from the extravascular compartment.