Cancer microRNAs: from subtype profiling to predictors of response to therapy.
Cancer microRNAs: from subtype profiling to predictors of response to therapy.
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DOI:
10.1016/j.molmed.2011.01.008
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发表时间:
2011-05
影响因子:
13.6
通讯作者:
Weidhaas JB
中科院分区:
文献类型:
--
作者:
Chan E;Prado DE;Weidhaas JB
MicroRNAs (miRNAs) are key regulators of gene expression that regulate important oncogenes and tumor suppressors. Many miRNAs act as oncogenes or tumor suppressors, and the altered misexpression of miRNAs is a hallmark of many cancer types. Dysregulated miRNAs are a potentially powerful new tool that could be used to enable the characterization of tumor environments and identify novel and important oncogenic pathways. More recently, there has been growing interest in the field of miRNAs as biomarkers of cancer risk, diagnosis and response to therapy. Understanding the associations between miRNA expression and cancer phenotypes, and the potential of miRNA profiling in clinical applications, promises to be highly rewarding in the field of cancer research.
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