Cancer microRNAs: from subtype profiling to predictors of response to therapy.

Cancer microRNAs: from subtype profiling to predictors of response to therapy.
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DOI:
10.1016/j.molmed.2011.01.008
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发表时间:
2011-05
影响因子:
13.6
通讯作者:
Weidhaas JB
Weidhaas JB
中科院分区:
医学1区
文献类型:
--
作者:
Chan E;Prado DE;Weidhaas JB

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MicroRNAs (miRNAs)是调控重要癌基因和肿瘤抑制基因表达的关键调控因子。许多mirna作为癌基因或肿瘤抑制因子,mirna的错误表达改变是许多癌症类型的标志。失调的mirna是一种潜在的强大的新工具,可用于表征肿瘤环境并识别新的和重要的致癌途径。最近,人们对mirna作为癌症风险、诊断和治疗反应的生物标志物越来越感兴趣。了解miRNA表达与癌症表型之间的关系,以及miRNA谱分析在临床应用中的潜力,有望在癌症研究领域获得高度回报。
MicroRNAs (miRNAs) are key regulators of gene expression that regulate important oncogenes and tumor suppressors. Many miRNAs act as oncogenes or tumor suppressors, and the altered misexpression of miRNAs is a hallmark of many cancer types. Dysregulated miRNAs are a potentially powerful new tool that could be used to enable the characterization of tumor environments and identify novel and important oncogenic pathways. More recently, there has been growing interest in the field of miRNAs as biomarkers of cancer risk, diagnosis and response to therapy. Understanding the associations between miRNA expression and cancer phenotypes, and the potential of miRNA profiling in clinical applications, promises to be highly rewarding in the field of cancer research.
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