Endothelium and mechanical responses of isolated monkey pulmonary veins to histamine.
Endothelium and mechanical responses of isolated monkey pulmonary veins to histamine.
复制标题
离体猴肺静脉对组胺的内皮和机械反应。
DOI：
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发表时间：
1990
影响因子：
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通讯作者：
T. Ohhashi
中科院分区：
文献类型：
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作者：
T. Matsuki;T. Ohhashi
用高浓度前列腺素F2 α（PGF 2 α）预收缩的猴肺静脉环条对组胺的反应呈浓度依赖性松弛。用美托洛尔和/或法莫替丁治疗可减弱松弛。2-吡啶基乙胺（2 PEA）和二甲双胍引起的松弛预收缩的准备，这是抑制预处理与美托咪胺和法莫替丁，分别。去除内皮逆转组胺和2 PEA诱导的舒张剂量相关的收缩。另一方面，去除对dimaprit-induced松弛没有影响，这是显着减少与法莫替丁预处理。组胺诱导的舒张预收缩带与内皮细胞在法莫替丁的存在和不存在的抑制或废除治疗与亚甲蓝或血红蛋白，但不受阿司匹林。可以得出结论，组胺诱导的松弛猴肺静脉PGF 2 α预收缩是由平滑肌中的H2受体和内皮中的H1受体介导的。此外，内皮H1受体的刺激释放内皮衍生的舒张因子。
Ring strips of monkey pulmonary veins precontracted with a high concentration of prostaglandin F2 alpha (PGF2 alpha) relaxed in a concentration-dependent manner in response to histamine. Treatment with mepyramine and/or famotidine attenuated the relaxation. 2-Pyridylethylamine (2PEA) and dimaprit caused relaxations in the precontracted preparations, which were inhibited by pretreatment with mepyramine and famotidine, respectively. Removal of endothelium reversed the histamine- and 2PEA-induced relaxations to dose-related contractions. On the other hand, the removal had no effect on the dimaprit-induced relaxations, which were significantly reduced by pretreatment with famotidine. Histamine-induced relaxations in the precontracted strips with endothelium in the presence and absence of famotidine were suppressed or abolished by treatment with methylene blue or hemoglobin but were unaffected by aspirin. It may be concluded that histamine-induced relaxation in monkey pulmonary veins precontracted with PGF2 alpha is mediated by H2-receptors in smooth muscle and H1-receptors in endothelium. Also, stimulation of the endothelial H1-receptors liberates an endothelium-derived relaxing factor.