ICMR TASK-FORCE STUDY ON HORMONAL CONTRACEPTION - BIOLOGICAL-ACTIVITY OF ETHINYL ESTRADIOL PRESENT IN THE BREAST-MILK
ICMR TASK-FORCE STUDY ON HORMONAL CONTRACEPTION - BIOLOGICAL-ACTIVITY OF ETHINYL ESTRADIOL PRESENT IN THE BREAST-MILK
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DOI：
10.1016/0010-7824(86)90069-7
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发表时间：
1986-08-01
期刊：
影响因子：
2.9
通讯作者：
SAXENA, BN
中科院分区：
文献类型：
--
作者：
BETRABET, SS;SHIKARY, ZK;SAXENA, BN
进行了一项研究，比较在哺乳期不同阶段收集的母乳样本中与从接受雌激素治疗的女性收集的母乳样本中内源性类固醇的雌激素成分的生物活性。通过未成熟小鼠子宫增重测定评估牛奶样品中的雌激素生物活性。将产后从六个不同研究组收集的乳汁样本（即 1-3 天和 4-6 天的对照初乳、过渡乳（10-20 天）和成熟乳（1-3 个月））与接受 Lynoral（乙炔雌二醇 0.1 mg）每天 3 次、持续三天的妇女的初乳和成熟乳进行比较。仅在注射了对照和 Lynoral 治疗女性初乳样品的乳提取物的动物中观察到雌激素活性；然而，它们之间并没有显着差异。因此，负责生物活性的不是外源雌激素，而是初乳中大量存在的内源雌激素。
A study was conducted to compare the biological activity of the estrogenic component of the endogenous steroids in breast milk samples collected during various phases of lactation with those milk samples collected form women who were on estrogen therapy. The estrogenic biological activity in the milk sample was assessed by the immature mouse uterine weight gain assay. Milk samples collected during post-partum period from six different study groups, viz., control colostrum of 1-3 days and 4-6 days, transitional milk (10-20 days) and mature milk (1-3 months) were compared with colostrum and mature milk of women treated with Lynoral (ethinyl estradiol 0.1 mg) three times a day for three days. Estrogenic activity was observed only in animals injected with milk extracts of colostrum samples from both control and Lynoral-treated women; however, they were not significantly different from each other. Therefore it is not the exogenous estrogens, but the endogenous estrogen present in large quantities in the colostrum that is responsible for the biological activity.