Peptide mediators of hypercalcemia in malignancy.
Peptide mediators of hypercalcemia in malignancy.
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DOI：
10.1146/annurev.me.41.020190.000343
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发表时间：
1990
影响因子：
10.5
通讯作者：
G. Strewler;R. Nissenson
中科院分区：
文献类型：
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作者：
G. Strewler;R. Nissenson
最近对一种可能导致与实体瘤相关的高钙血症的甲状旁腺激素样肽进行了表征。它是一种有效的高钙血症和低磷血症因子，其产生与高钙血症密切相关，其特性解释了临床综合征的大部分方面。这种肽的诊断测试已经开发出来。甲状旁腺激素样肽以及其他细胞因子，例如肿瘤坏死因子-α，可能在引起多发性骨髓瘤和淋巴瘤中的高钙血症中发挥作用。
A parathyroid hormone-like peptide that probably causes hypercalcemia associated with solid tumors was recently characterized. It is a potent hypercalcemic and hypophosphatemic factor whose production is strongly associated with hypercalcemia and whose properties account for most aspects of the clinical syndrome. Diagnostic tests for this peptide have been developed. The parathyroid hormone-like peptide as well as other cytokines, such as tumor necrosis factor-alpha, likely play a role in causing hypercalcemia in multiple myeloma and lymphomas.