Crucial factors and emerging concepts in ultrasound-triggered drug delivery
Crucial factors and emerging concepts in ultrasound-triggered drug delivery
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DOI：
10.1016/j.jconrel.2012.08.014
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发表时间：
2012-12-28
影响因子：
10.8
通讯作者：
Lentacker, Ine
中科院分区：
文献类型：
--
作者：
Geers, Bart;Dewitte, Heleen;Lentacker, Ine
时间和空间控制的药物输送在医学上仍然是一个巨大的挑战。一种可以提供解决方案的新方法是超声波引导的药物输送。“超声波给药”通常是基于使用小气泡(所谓的微气泡)，当暴露在超声波下时，这些气泡会振荡和空化。一些微泡是FDA批准的超声成像造影剂，目前被广泛研究为有前途的药物载体。事实上，已经观察到，当暴露在超声波下时，微泡可以(A)释放被包裹的药物，(B)同时改变与微泡接触的细胞膜的结构，这可能有助于药物进入细胞。本综述旨在强调(A)目前已知的影响超声药物输送的主要因素(如微泡的结构、声学设置等)。以及(B)总结了这一领域的最新临床前进展，以及一些有前途的新概念和应用。(C)2012年由爱思唯尔出版。
Time and space controlled drug delivery still remains a huge challenge in medicine. A novel approach that could offer a solution is ultrasound guided drug delivery. "Ultrasonic drug delivery" is often based on the use of small gas bubbles (so-called microbubbles) that oscillate and cavitate upon exposure to ultrasound waves. Some microbubbles are FDA approved contrast agents for ultrasound imaging and are nowadays widely investigated as promising drug carriers. Indeed, it has been observed that upon exposure to ultrasound waves, microbubbles may (a) release the encapsulated drugs and (b) simultaneously change the structure of the cell membranes in contact with the microbubbles which may facilitate drug entrance into cells. This review aims to highlight (a) major factors known so far which affect ultrasonic drug delivery (like the structure of the microbubbles, acoustic settings, etc.) and (b) summarizes the recent preclinical progress in this field together with a number of promising new concepts and applications. (C) 2012 Published by Elsevier BV.