A COMPARATIVE-STUDY OF EPENDYMOMAS BY SITE OF ORIGIN
A COMPARATIVE-STUDY OF EPENDYMOMAS BY SITE OF ORIGIN
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DOI：
10.1016/0360-3016(82)90382-0
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发表时间：
1982-01-01
影响因子：
7
通讯作者：
ADLER, SJ
中科院分区：
文献类型：
--
作者：
MARKS, JE;ADLER, SJ
组织学证实的室管膜瘤患者(61例)在1954-1976年间接受了放射治疗。幕上和幕下肿瘤更常见于儿童，而脊髓-马尾神经肿瘤更常见于成人。幕上肿瘤4例，幕下肿瘤26例，髓内肿瘤7例，马尾神经肿瘤7例。对于接受较高生物有效剂量放射的患者，幕下肿瘤的局部控制有所改善，但幕上、脊髓或马尾肿瘤没有发现剂量反应。5年的精算生存率为56%，幕上为35%，幕下为59%，脊髓为57%，马尾肿瘤为83%。在46例枕大孔以上室管膜瘤患者中，有5例(11%)被病理证实为脊柱转移。有2名患者临床表现明显，最常见的是脊椎未受过照射的幕下肿瘤患者。1例因马尾神经肿瘤接受外照射的患者1.5年后出现放射性脊髓病；8例鞘内注射GOLD-198的患者中有3例在3.5-17年后出现脊髓病和/或马尾神经综合征。
Patients (61) with histologically proven ependymoma were irradiated between 1954-1976. Supra- and infratentorial tumors occurred more often in children and spinal cord-cauda equina tumors more often in adults. Local control was achieved in 4 of 20 supratentorial, 13 of 26 infratentorial, 3 of 7 intramedullary spinal cord, and 7 of 8 cauda equina tumors. Improved local control of infratentorial tumors was noted for patients who received higher biologically effective doses of radiation but no dose-response for supratentorial, spinal cord or cauda equina tumors could be found. Five-year actuarial survival was 56% for all patients, 35% for supratentorial, 59% for infratentorial, 57% for spinal cord and 83% for cauda equina tumors. Spinal metastases were pathologically documented in 5 of 46 (11%) patients with ependymomas above the foramen magnum. They were clinically evident in 2 patients and most common in patients with infratentorial tumors whose spines had not been irradiated. One patient who was irradiated externally for cauda equina tumor developed radiation myelopathy 1.5 yr later; 3 of 8 patients who received intrathecal gold-198 developed myelopathy and/or cauda equina syndrome 3.5-17 yr later.