Impaired effective cortical connectivity in vegetative state: Preliminary investigation using PET
Impaired effective cortical connectivity in vegetative state: Preliminary investigation using PET
复制标题
植物人状态下大脑皮层的有效连通性受损： 使用 PET 进行初步研究
DOI：
10.1006/nimg.1998.0414
复制
发表时间：
1999-04-01
期刊：
影响因子：
5.7
通讯作者：
Maquet, P
中科院分区：
文献类型：
--
作者：
Laureys, S;Goldman, S;Maquet, P
植物人状态（VS）是一种意识消失并伴有持续性觉醒的状态。意识是意识的一部分，意识本身被认为是大脑神经网络的一种涌现特性。我们的假设是，VS背后的部分神经相关性是一种改变的连接性，特别是在联合皮层之间。我们通过统计参数图和[F-18]氟脱氧葡萄糖正电子发射断层扫描评估了4例VS患者的局部脑葡萄糖代谢（rCMRGlu）和有效皮质连接。我们的数据显示了一个共同的模式受损的rCMRGlu在前额叶，运动前区，顶叶颞叶联合区和后扣带皮层/楔前叶在VS。在下一步中，我们表明，在VS患者的各种前额叶和运动前区的共同点，他们是不那么紧密地连接后扣带皮层比正常对照组。这些结果提供了一个强有力的论据VS患者的皮质连接的改变。(C)北京：科学出版社.
Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural networks. Our hypothesis was that part of the neural correlate underlying VS is an altered connectivity, especially between the associative cortices. We assessed regional cerebral glucose metabolism (rCMRGlu) and effective cortical connectivity in four patients in VS by means of statistical parametric mapping and [F-18]fluorodeoxyglucose-positron emission tomography. Our data showed a common pattern of impaired rCMRGlu in the prefrontal, premotor, and parietotemporal association areas and posterior cingulate cortex/precuneus in VS. In a next step, we demonstrated that in VS patients various prefrontal and premotor areas have in common that they are less tightly connected with the posterior cingulate cortex than in normal controls. These results provide a strong argument for an alteration of cortical connectivity in VS patients. (C) 1999 Academic Press.