Are there multiple cells of origin of Merkel cell carcinoma?
Are there multiple cells of origin of Merkel cell carcinoma?
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DOI：
10.1038/s41388-017-0073-3
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发表时间：
2018-03
期刊：
影响因子：
8
通讯作者：
Choi J
中科院分区：
文献类型：
--
作者：
Sunshine JC;Jahchan NS;Sage J;Choi J
Merkel cell carcinoma (MCC) is a rare but lethal cancer with the highest case-by-case fatality rate among all skin cancers. 80% of cancers are associated with the Merkel cell polyomavirus (MCPyV). 20% of MCCs are virus negative. Recent epidemiological data suggest that there are important, clinically relevant differences between these two subtypes of MCC. Recent studies in cancer genomics, mouse genetics, and virology experiments have transformed our understanding of MCC pathophysiology. Importantly, dramatic differences in the genetics of these two MCC subtypes suggest fundamental differences in their pathophysiology. We review these recent works and find that they provocatively suggest that MCPyV-positive and MCPyV-negative MCCs arise from two different cells of origin: the MCPyV-negative MCC from epidermal keratinocytes and the MCPyV-positive MCC from dermal fibroblasts. If true, this would represent the first cancer that we are aware of that evolves from cells of origin from two distinct germ layers: MCPyV-negative MCCs from ectodermal keratinocytes and MCPyV-positive MCCs from mesodermal fibroblasts. Future epigenetic experiments may prove valuable in confirming these distinct lineages for these MCC subtypes, especially for the clinical importance the cell of origin has on MCC treatment and prevention.
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影响因子：
4.3
作者：
Choi, Jaehyuk;Landrette, Sean F.;Xu, Tian
通讯作者：
Xu, Tian
DOI：
10.1016/s1470-2045(16)30364-3
发表时间：
2016-10
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Kaufman HL;Russell J;Hamid O;Bhatia S;Terheyden P;D'Angelo SP;Shih KC;Lebbé C;Linette GP;Milella M;Brownell I;Lewis KD;Lorch JH;Chin K;Mahnke L;von Heydebreck A;Cuillerot JM;Nghiem P
通讯作者：
Nghiem P
DOI：
10.1158/1541-7786.mcr-13-0554
发表时间：
2014-05
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Cui M;Augert A;Rongione M;Conkrite K;Parazzoli S;Nikitin AY;Ingolia N;MacPherson D
通讯作者：
MacPherson D
影响因子：
11.2
作者：
Harms PW;Vats P;Verhaegen ME;Robinson DR;Wu YM;Dhanasekaran SM;Palanisamy N;Siddiqui J;Cao X;Su F;Wang R;Xiao H;Kunju LP;Mehra R;Tomlins SA;Fullen DR;Bichakjian CK;Johnson TM;Dlugosz AA;Chinnaiyan AM
通讯作者：
Chinnaiyan AM
DOI：
10.1097/pas.0b013e3181aa30a5
发表时间：
2009-09
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Busam KJ;Jungbluth AA;Rekthman N;Coit D;Pulitzer M;Bini J;Arora R;Hanson NC;Tassello JA;Frosina D;Moore P;Chang Y
通讯作者：
Chang Y