Growth of measles virus in the lymphoid tissues of monkeys.
Growth of measles virus in the lymphoid tissues of monkeys.
复制标题
麻疹病毒在猴子淋巴组织中的生长。
DOI：
--
复制
发表时间：
1973
影响因子：
6.4
通讯作者：
T. Tsuruhara
中科院分区：
文献类型：
--
作者：
K. Yamanouchi;F. Chino;F. Kobune;H. Kodama;T. Tsuruhara
本文应用免疫荧光技术和光镜技术对麻疹野病毒感染猴的淋巴组织进行了观察。病毒抗原的分布与巨细胞有较好的相关性，巨细胞多为网状型。巨细胞内常检测到大量病毒抗原，提示巨细胞可能是麻疹病毒原位生长的结果。麻疹病毒主要生长部位为脾脏、淋巴结和扁桃体。胸腺和盲肠的受累程度也可能低于其他淋巴器官。未获得骨髓中病毒生长的证据。网状细胞可能是麻疹病毒生长的主要靶细胞。
The lymphoid tissues of monkeys infected with wild measles virus were examined by light microscopy and the fluorescent antibody technique. There was a good correlation between distribution of viral antigen and giant cells, most of which were of the reticular type. A large amount of viral antigen was always detected in giant cells, which suggested that these cells might be formed as a result of growth of measles virus in situ. Major growth sites of measles virus were found to be as the spleen, lymph nodes, and tonsils. It also appeared that the thymus and cecum might be involved to a lesser extent than the other lymphoid organs. Evidence of growth of virus in the bone marrow was not obtained. The possibility that the reticular cells are a main target of growth of measles virus was considered.