The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
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生物系统中的 Gabriel-Colman 重排：邻苯二甲酰亚胺和糖精衍生物的设计、合成和生物学评价，作为人类白细胞弹性蛋白酶、组织蛋白酶 G 和蛋白酶 3 的潜在机制抑制剂。
DOI：
10.1016/0968-0896(95)00013-7
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发表时间：
1995
影响因子：
3.5
通讯作者：
Hoidal,JR
中科院分区：
文献类型：
--
作者：
Groutas,WC;Chong,LS;Venkataraman,R;Epp,JB;Kuang,R;Houser-Archield,N;Hoidal,JR
一系列的邻苯二甲酰亚胺和糖精衍生物与白细胞弹性蛋白酶，组织蛋白酶G和蛋白酶3的相互作用的构效关系研究的结果进行了描述。发现邻苯二甲酰亚胺衍生物是无活性的，而发现一些糖精衍生物是这些酶的公平抑制剂。
The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.