Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine.
Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine.
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DOI：
10.1176/ajp.139.11.1421
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发表时间：
1982-11
期刊：
影响因子：
--
通讯作者：
K. Davis;R. Mohs
中科院分区：
文献类型：
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作者：
K. Davis;R. Mohs
10名无抗精神病药的阿尔茨海默病患者在30分钟内静脉注射毒扁豆碱（0.125 mg、0.25 mg或0.50 mg）或安慰剂。所有患者在接受毒扁豆碱治疗时，在识别记忆任务上表现更好。当安慰剂或毒扁豆碱的剂量与记忆的改善是重新开始，毒扁豆碱再次提高识别记忆任务的性能。这些结果表明，一些阿尔茨海默病患者胆碱能活动的急性增强可以部分逆转该疾病的记忆缺陷，并可能为这种疾病的最终治疗提供一种方法。
Physostigmine (.125 mg, .25 mg, or .50 mg) or placebo was administered intravenously to 10 neuroleptic-free patients with Alzheimer's disease over a 30-minute period. All patients performed better on a recognition memory task while receiving physostigmine. When placebo or the dose of physostigmine previously associated with an improvement in memory was readministered, physostigmine again enhanced performance on a recognition memory task. These results indicate that the acute augmentation of cholinergic activity in some patients with Alzheimer's disease can partially reverse the memory deficit of that disorder and may provide an approach to the eventual therapy of this condition.