DIFFERENTIAL DIAGNOSTIC FEATURES OF NODULAR L AND H HODGKINS-DISEASE, INCLUDING PROGRESSIVE TRANSFORMATION OF GERMINAL-CENTERS
DIFFERENTIAL DIAGNOSTIC FEATURES OF NODULAR L AND H HODGKINS-DISEASE, INCLUDING PROGRESSIVE TRANSFORMATION OF GERMINAL-CENTERS
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DOI：
10.1097/00000478-198404000-00002
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发表时间：
1984-01-01
影响因子：
5.6
通讯作者：
DORFMAN, RF
中科院分区：
文献类型：
--
作者：
BURNS, BF;COLBY, TV;DORFMAN, RF
本文报告了171例淋巴细胞为主型（L和H）结节性霍奇金病的组织学特征，并讨论了与一种称为进行性转化生发中心（PTGC）的异常滤泡增生的关系。PTGC与L型和H型霍奇金病的结节相似，18%的病例两个结节同时存在于同一淋巴结内。2例淋巴结活检显示PTGC，活检显示结节性L和H霍奇金病，3例组织学证实的霍奇金病患者在随后的淋巴结活检中发现PTGC。对3例结节性L和H型霍奇金病冰冻切片的免疫学研究表明，瘤性结节内含有丰富的树突状网状细胞和B淋巴细胞，并有散在的T淋巴细胞。这些发现表明PTGC与结节性L和H型霍奇金病之间的关联更为巧合，并且这种形式的霍奇金病优先累及淋巴结的B细胞区域，与这种疾病的其他形式的T区分布相反。
The histologic features in 171 cases of nodular lymphocyte-predominant (L and H) Hodgkin''s disease are presented and the association with an abnormal form of follicular hyperplasia termed progressively transformed germinal centers (PTGC) [by Lennert] is discussed. PTGC may closely resemble the nodules of L and H Hodgkin''s disease, and in 18% of the cases the 2 processes coexisted in the same lymph node. Two patients had lymph node biopsies showing PTGC prior to biopsies showing nodular L and H Hodgkin''s disease and 3 patients with histologically proved Hodgkin''s disease were found to have PTGC in subsequent lymph node biopsies. Immunologic studies on frozen tissue sections from 3 cases of nodular L and H Hodgkin''s disease showed that the neoplastic nodules contained abundant dendritic reticulum cells and B-lymphocytes with scattered T-lymphocytes. These findings suggest that the association between PTGC and nodular L and H Hodgkin''s disease is more coincidental, and that this form of Hodgkin''s disease preferentially involves B cell areas of the lymph node, in contrast to the T-zone distribution in other forms of this disorder.