Epidemiology of sepsis in Germany: results from a national prospective multicenter study
Epidemiology of sepsis in Germany: results from a national prospective multicenter study
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DOI：
10.1007/s00134-006-0517-7
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发表时间：
2007-04-01
影响因子：
38.9
通讯作者：
Reinhart, Konrad
中科院分区：
文献类型：
--
作者：
Engel, Christoph;Brunkhorst, Frank M.;Reinhart, Konrad
目的：确定德国ICU严重脓毒症患者的患病率和死亡率，并考虑医院规模。设计：前瞻性、观察性、横断面1天时点患病率研究。设置：454个ICU，来自全国310家医院的代表性样本，按规模分层。由经过培训的外部研究医生通过为期1天的现场稽查收集数据。访问随机分布在1年（2003年）。患者：使用ACCP/SCCM共识会议标准评估所有ICU患者的炎症反应。严重脓毒症患者在3个月后随访住院死亡率和ICU住院时间。测量和结果：主要的结果指标是患病率和死亡率。共有3，877名患者接受了筛查。脓毒症的患病率为12.4%（95% CI，10.9-13.8%），严重脓毒症（包括脓毒性休克）的患病率为11.0%（95% CI，9.7-12.2%）。重症脓毒症患者的ICU和住院死亡率分别为48.4%和55.2%，不同医院规模之间无显著差异。在大医院和大学中，严重脓毒症患者的患病率和ICU平均住院时间显著更高（
Objective: To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size. Design: Prospective, observational, cross-sectional 1-day point-prevalence study. Setting: 454 ICUs from a representative nationwide sample of 310 hospitals stratified by size. Data were collected via 1-day on-site audits by trained external study physicians. Visits were randomly distributed over 1 year (2003). Patients: Inflammatory response of all ICU patients was assessed using the ACCP/SCCM consensus conference criteria. Patients with severe sepsis were followed up after 3 months for hospital mortality and length of ICU stay. Measurements and results: Main outcome measures were prevalence and mortality. A total of 3,877 patients were screened. Prevalence was 12.4% (95% CI, 10.9-13.8%) for sepsis and 11.0% (95% CI, 9.7-12.2%) for severe sepsis including septic shock. The ICU and hospital mortality of patients with severe sepsis was 48.4 and 55.2%, respectively, without significant differences between hospital size. Prevalence and mean length of ICU stay of patients with severe sepsis were significantly higher in larger hospitals and universities (