Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2.
Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2.
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新发现的前列腺素 PGI2 的肺和全身血管舒张作用。
DOI：
10.1152/jappl.1978.45.3.408
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
E. Spannhake
中科院分区：
文献类型：
--
作者：
P. Kadowitz;B. Chapnick;L. Feigen;A. Hyman;P. K. Nelson;E. Spannhake
在麻醉犬中研究了新发现的双环前列腺素前列环素（PGI_2）对肺和体循环血管床的影响。当将1- 30微克剂量的PGI_2注入腔静脉时，以剂量相关的方式降低全身和肺动脉压。由于左心室舒张末期、左心房和右心房压力不变，并且由于心输出量增加或不变，肺和全身血管阻力降低。当静脉注射时，PGI_2在降低主动脉压方面的效力是E_1或E_2的10倍，当注射到腔静脉或左心房时，PGI_2对全身血管床的作用相似。这些数据表明，PGI 2在肺中的失活是最小的。稳定的前列环素代谢物6-keto-PGF 1 α几乎没有血流动力学效应，表明对PGI 2的反应不是由于该代谢物的形成。PGI 2产生剂量依赖性增加血流量在肠系膜和肾血管床。这些数据表明，PGI 2在肺和全身血管床中具有显著的血管扩张活性，并表明前列环素是花生四烯酸扩张肺和全身循环的唯一已知代谢物。
The effects of the newly discovered bicyclic prostaglandin, prostacyclin (PGI2), on the pulmonary and systemic vascular beds were investigated in the anesthetized dog. PGI2 decreased systemic and pulmonary arterial pressures in a dose-related manner when injected into the vena cava in doses of 1--30 microgram. Since left ventricular end-diastolic, left atrial, and right atrial pressures were unchanged, and since cardiac output was increased or unchanged, pulmonary and systemic vascular resistances were decreased. PGI2 was 10 times more potent than prostaglandins E1 or E2 in decreasing aortic pressure when injected intravenously, and the effects of PGI2 on the systemic vascular bed were similar when injected into the vena cava or the left atrium. These data indicate that inactivation of PGI2 is minimal in the lung. The stable prostacyclin metabolite, 6-keto-PGF1alpha, had little hemodynamic effects, suggesting that responses to PGI2 were not due to formation of this metabolite. PGI2 produced dose-dependent increases in blood flow in the mesenteric and renal vascular beds. These data demonstrate that PGI2 has marked vasodilator activity in the pulmonary and systemic vascular beds and suggest that prostacyclin is the only known metabolite of arachidonic acid that dilates the pulmonary and systemic circulations.