A link between type 2 diabetes and brain function.
A link between type 2 diabetes and brain function.
复制标题
2 型糖尿病与大脑功能之间的联系。
DOI：
10.1097/01.jaa.0000437750.76865.61
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Hugenschmidt,ChristinaE
中科院分区：
文献类型：
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作者：
Hugenschmidt,ChristinaE
Christina E. Hugenschmidt, PhD sis, hypertension, heart failure, stroke, and myocardial infarction. Cardiovascular disease, in turn, increases the risk of dementia and milder cognitive impairments independent of diabetes. 9 One illustration of this link is hypertension. Hypertension is a common comorbidity of type 2 diabetes that is associated with atrophy of overall grey matter, the hippocampus, and the frontal cortex. 10, 11Hypertension is also strongly associated with leukoaraiosis, a disease of white matter in the brain that is common in aging and associated with slower processing speed. 11, 12 In a postmortem study in humans with Alzheimer disease, although patients with diabetes had a comparable level of Alzheimer pathology to those without diabetes, the patients with diabetes were more likely to experience cerebral infarctions. 13 In short, the risk of clinically diagnosed cardiovascular disease in patients with type 2 diabetes almost assuredly raises their risk of cognitive decline. My colleagues and I recently analyzed data from a large genetic study to see if evidence of subclinical cardiovascular disease raised the risk of poorer cognitive function a few years later. In our study, subclinical cardiovascular disease was defined as coronary calcification measured using computed tomography. Part of what made this study unique was that we included a measure of subclinical cardiovascular disease, rather than reported cardiovascular events. Also, we studied a group of aging siblings in whom about 80% had type 2 diabetes. Why is this population important to study? First, because they share some genetic and environmental background, these factors are less likely to explain any observed differences between those with and without diabetes. Second, the siblings without diabetes were not healthy controls, as are most commonly used. Some of our patients also had
