Obesity and Polycystic Ovary Syndrome.
Obesity and Polycystic Ovary Syndrome.
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DOI：
10.1089/obe.2007.0019
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发表时间：
2007-04-01
期刊：
影响因子：
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通讯作者：
Sam, Susan
中科院分区：
文献类型：
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作者：
Sam, Susan
自1935年Stein和Leventhal首次描述以来，肥胖已被认为是多囊卵巢综合征（PCOS）的共同特征。在美国，一些研究报告称，PCOS女性超重和肥胖的患病率高达80%。在美国以外，受影响女性的肥胖患病率较低，尽管随着时间的推移而增加，研究报告的患病率低至20%。PCOS诊断标准的差异解释了患病率的一些差异。然而，即使采用可比的诊断标准，肥胖的患病率和严重程度在美国以外的PCOS女性中也较低。这一观察结果表明，环境因素，如生活方式，有助于PCOS中肥胖的存在。PCOS和肥胖之间的一致关联表明了这一观察结果的生物学基础。此外，肥胖加剧了许多与PCOS相关的生殖和代谢异常。本综述探讨了现有的数据，这种协会的机制。
Since its original description in 1935 by Stein and Leventhal, obesity has been recognized as a common feature of the polycystic ovary syndrome (PCOS). In the United States, some studies report that the prevalence of overwieght and obesity in women with PCOS is as high as 80%. Outside the US, the prevalence of obesity in affected women is lower, although it has increased over time, with studies reporting rates as low as 20%. Differences in the diagnostic criteria for PCOS account for some of this difference in prevalence rates. However, even when comparable diagnostic criteria are applied, both the prevalence and severity of obesity are lower in women with PCOS outside the US This observation suggests that environmental factors, such as lifestyle, contribute to the presence of obesity in PCOS. The consistent association between PCOS and obesity suggests a biologic basis for this observation. Moreover, obesity exacerbates many of the reproductive and metabolic abnormalities associated with PCOS. This review explores the available data on the mechanisms of this association.