Pharmacokinetics of hydroxyurea 1,000 mg coated breakable tablets and 500 mg capsules in pediatric and adult patients with sickle cell disease.
Pharmacokinetics of hydroxyurea 1,000 mg coated breakable tablets and 500 mg capsules in pediatric and adult patients with sickle cell disease.
复制标题
羟基脲 1,000 毫克包衣易碎片和 500 毫克胶囊在镰状细胞病儿童和成人患者中的药代动力学。
作者：
M. de Montalembert;D. Bachir;A. Hulin;L. Gimeno;A. Mogenet;J. Bresson;I. Macquin‐Mavier;F. Roudot;A. Astier;F. Galactéros
Little is known about the pharmacokinetics of hydroxyurea in patients with sickle cell disease (SCD). Our aims were to evaluate bioequivalence between standard hydroxyurea capsules and a new formulation of 1,000 mg coated breakable tablets in adults and to compare pharmacokinetic parameters in adults and children with SCD. Fifteen adults received hydroxyurea capsules and tablets in a randomized cross-over study. Eleven children received hydroxyurea tablets. The results showed bioequivalence between capsules and tablets in adults. Pharmacokinetic parameters were not significantly different between adults and children. Considerable inter-individual variability was noted.
DOI：
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发表时间：
2001-05
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
E. Raymond;S. Faivre;G. Weiss;J. McGill;K. Davidson;E. Izbicka;J. Kuhn;C. Allred;G. Clark
通讯作者：
E. Raymond;S. Faivre;G. Weiss;J. McGill;K. Davidson;E. Izbicka;J. Kuhn;C. Allred;G. Clark
镰状细胞性贫血中的胎儿血红蛋白：对羟基脲反应的决定因素。
影响因子：
20.3
作者：
Steinberg,MH;Lu,ZH;Barton,FB;Terrin,ML;Charache,S;Dover,GJ
通讯作者：
Dover,GJ
影响因子：
158.5
作者：
CHARACHE, S;TERRIN, ML;WACLAWIW, M
通讯作者：
WACLAWIW, M