Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers
Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers
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DOI：
10.1097/qad.0b013e32826fbc54
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发表时间：
2007-10-18
期刊：
影响因子：
3.8
通讯作者：
Grunfeld, Carl
中科院分区：
文献类型：
--
作者：
Lee, Grace A.;Rao, Madhu;Grunfeld, Carl
背景：一些 HIV 蛋白酶抑制剂 (Pls) 已被证明可在体外诱导胰岛素抵抗，但具体 Pi 影响人类胰岛素敏感性的程度尚不清楚。方法：在两项独立的双盲、随机、交叉研究中，我们评估了单剂量利托那韦 (800 mg) 和安普那韦 (1200 mg) 对胰岛素敏感性的影响 结果：利托那韦降低了胰岛素敏感性（-15%；与安慰剂相比，P=0.008）和非氧化葡萄糖处理能力（-30%；P=0.0004），而安普那韦给药均不受影响。结论：与之前使用单剂量茚地那韦和 洛匹那韦/利托那韦，观察到胰岛素抵抗的等级，其中茚地那韦效果最大，其次是利托那韦和洛匹那韦/利托那韦，安普那韦效果甚微。 (C) 2007 年威科健康 |利平科特·威廉姆斯和威尔金斯。
Background: Some HIV protease inhibitors (Pls) have been shown to induce insulin resistance in vitro but the degree to which specific Pis affect insulin sensitivity in humans is less well understood.Methods: In two separate double-blind, randomized, cross-over studies, we assessed the effects of a single dose of ritonavir (800 mg) and amprenavir (1200 mg) on insulin sensitivity (euglycemic hyperglycemic clamp) in healthy normal volunteers.Results: Ritonavir decreased insulin sensitivity (-15%; P=0.008 versus placebo) and non-oxidative glucose disposal (-30%; P=0.0004), whereas neither were affected by amprenavir administration.Conclusion: Compared to previously performed studies of identical design using single doses of indinavir and lopinavir/ritonavir, a hierarchy of insulin resistance was observed with the greatest effect seen with indinavir followed by ritonavir and lopinavir/ritonavir, with little effect of amprenavir. (C) 2007 Wolters Kluwer Health | Lippincott Williams & Wilkins.