Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology
Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology
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DOI：
10.1016/j.ophtha.2005.05.027
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发表时间：
2005-11-01
期刊：
影响因子：
13.7
通讯作者：
Duker, JS
中科院分区：
文献类型：
--
作者：
Ko, TH;Fujimoto, JG;Duker, JS
目的：比较超高分辨率光学相干断层扫描(UHR OCT)与标准分辨率光学相干断层扫描(UHR OCT)对黄斑部疾病的诊断价值，探讨超高分辨率光学相干断层扫描(UHR OCT)对黄斑病变的诊断价值。设计：横断面研究。研究对象：555例(102只眼)黄斑病变患者，包括黄斑裂孔、黄斑水肿、中心性浆液性脉络膜视网膜病变、老年性黄斑变性、脉络膜新生血管、视网膜前膜、视网膜色素上皮(RPE)脱离、视网膜色素沉着。使用UHR OCT和标准10微米分辨率OCT进行对比研究。两个系统都获得了通过中心凹的6次6 mm径向扫描的标准扫描方案。超高分辨率OCT和标准分辨率OCT图像与标准眼科检查技术(扩张眼底镜、荧光素血管造影、吲哚青绿血管造影)相关联，以评估图像中包含的形态信息。结果：全层黄斑裂孔、中心性浆液性脉络膜视网膜病变、黄斑水肿、AMD、RPE脱离、视网膜前膜、玻璃体黄斑牵引和视网膜色素变性患者的超高分辨率OCT图像、标准分辨率图像、眼底检查和/或荧光血管造影均显示出相关性。超高分辨率OCT和标准分辨率OCT在区分较厚的视网膜层方面表现出相似的性能，如视网膜神经纤维、内外丛和内核和外核。超高分辨率OCT具有更好的区分细微结构或低对比度结构的性能，如神经节细胞层和外界膜。超高分辨率OCT证实了对特征的解释，例如光感受器内外节段之间的边界，这在标准分辨率OCT中也是可见的。结论：超高分辨率OCT较标准分辨率OCT增强了视网膜内结构形态的可视化。超高分辨率OCT图像可以为定义标准分辨率图像的解释提供基线，从而增强标准OCT成像的临床实用性。此外，UHR OCT可以提供有关黄斑疾病形态的额外信息，有望改善对疾病进展和治疗的了解。
Objective: To compare ultrahigh-resolution optical coherence tomography (UHR OCT) with standard-resolution OCT for imaging macular diseases, develop baselines for interpreting OCT images, and identify situations where UHR OCT can provide additional information on disease morphology.Design: Cross-sectional study.Participants: One thousand two eyes of 555 patients with different macular diseases including macular hole, macular edema, central serous chorioretinopathy, age-related macular degeneration (AMD), choroidal neovascularization, epiretinal membrane, retinal pigment epithelium (RPE) detachment, and retinitis pigmentosa.Methods: A UHR ophthalmic OCT system that achieves 3-mu m axial image resolution was developed for imaging in the ophthalmology clinic. Comparative studies were performed with both UHR OCT and standard 10-mu m-resolution OCT. Standard scanning protocols of 6 radial 6-mm scans through the fovea were obtained with both systems. Ultrahigh-resolution OCT and standard-resolution OCT images were correlated with standard ophthalmic examination techniques (dilated ophthalmoscopy, fluorescein angiography, indocyanine green angiograms) to assess morphological information contained in the images.Main Outcome Measures. Ultrahigh-resolution and standard-resolution OCT images of macular pathologies.Results: Correlations of UHR OCT images, standard-resolution images, fundus examination, and/or fluorescein angiography were demonstrated in full-thickness macular hole, central serous chorioretinopathy, macular edema, AMD, RPE detachment, epiretinal membrane, vitreal macular traction, and retinitis pigmentosa. Ultrahigh-resolution OCT and standard-resolution OCT exhibited comparable performance in differentiating thicker retinal layers, such as the retinal nerve fiber, inner and outer plexiform, and inner and outer nuclear. Ultrahigh-resolution OCT had improved performance differentiating finer structures or structures with lower contrast, such as the ganglion cell layer and external limiting membrane. Ultrahigh-resolution OCT confirmed the interpretation of features, such as the boundary between the photoreceptor inner and outer segments, which is also visible in standard-resolution OCT. The improved resolution of UHR OCT is especially advantageous in assessing photoreceptor morphology.Conclusions: Ultrahigh-resolution OCT enhances the visualization of intraretinal architectural morphology relative to standard-resolution OCT. Ultrahigh-resolution OCT images can provide a baseline for defining the interpretation of standard-resolution images, thus enhancing the clinical utility of standard OCT imaging. In addition, UHR OCT can provide additional information on macular disease morphology that promises to improve understanding of disease progression and management.