Effects of Mandibular Deviation on Brain Activation During Clenching: An fMRI Preliminary Study
Effects of Mandibular Deviation on Brain Activation During Clenching: An fMRI Preliminary Study
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DOI：
10.1179/crn.2009.014
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发表时间：
2009-04-01
影响因子：
1.6
通讯作者：
Sasaguri, Kenichi
中科院分区：
文献类型：
--
作者：
Otsuka, Takero;Watanabe, Kazuko;Sasaguri, Kenichi
本研究利用功能性磁共振成像(FMRI)对8名健康受试者进行了咬合错合模型咬合时血氧水平依赖(BOLD)信号的测量，使用定制的强制下颌后缩位置的夹板和未修改的夹板作为对照，并将结果与相应休息条件下的BOLD信号进行比较。在咬合过程中，还检查了个体视觉模拟评分(VAS)，以评估功能磁共振数据与精神变化之间的交互作用。在这两个紧握过程中，可以看到四个脑区(运动前皮质、前额叶皮质、感觉运动皮质和脑岛)的激活。然而，咬合不良模型中，伴随着心理不适的咬合，额外增加了前扣带皮质和杏仁核的大胆信号。此外，这两个区域的BOLD信号强度与VAS评分之间存在平行关系。这一发现可能表明，咬合不良与大脑中与情绪和/或疼痛相关的神经处理有关。
Using functional magnetic resonance imaging (fMRI) in eight healthy human subjects, the present study measured blood oxygenation level-dependent (BOLD) signals during clenching in a malocclusion model, using a custom-made splint that forced the mandible to a retrusive position and a splint of no modification for control, and compared the results to the BOLD signals during the corresponding resting conditions. An individual visual analog scale (VAS) score was also examined during clenching to evaluate the interactions between fMRI data and psychiatric changes. During both clenchings, activations in four brain regions (premotor cortex, prefrontal cortex, sensorimotor cortex, and insula) were seen. However, clenching in the malocclusion model, with psychological discomfort, increased additionally BOLD signals in the anterior cingulate cortex and the amygdala. Furthermore, there was a parallel relationship between BOLD signal intensities and VAS scores in these two regions. The findings may suggest the involvement of clenching with malocclusal conditions in the emotion and/or pain-related neural processing in the brain.