Dynamics of blood flow and oxygenation changes during brain activation: The balloon model
Dynamics of blood flow and oxygenation changes during brain activation: The balloon model
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DOI：
10.1002/mrm.1910390602
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发表时间：
1998-06-01
影响因子：
3.3
通讯作者：
Frank, LR
中科院分区：
文献类型：
--
作者：
Buxton, RB;Wong, EC;Frank, LR
本文提出了一个脑激活过程中脱氧血红蛋白含量动态变化的生物力学模型，该模型考虑了血氧和血容量动态变化的相互矛盾的影响，基于该模型的计算表明，脱氧血红蛋白含量和功能磁共振测量的血氧水平依赖（BOLD）信号有明显的瞬变，包括BOLD信号的初始下降和过冲以及延长的刺激后下冲。此外，这些短暂的影响可能会发生在整个激活期的脑血流和氧代谢的紧密耦合的存在下。对实验测量的流量和BOLD的变化，在一个手指轻敲任务的模型的初步测试显示出良好的一致性。
A biomechanical model is presented for the dynamic changes in deoxyhemoglobin content during brain activation, The model incorporates the conflicting effects of dynamic changes in both blood oxygenation and blood volume, Calculations based on the model show pronounced transients in the deoxyhemoglobin content and the blood oxygenation level dependent (BOLD) signal measured with functional MRI, including initial dips and overshoots and a prolonged poststimulus undershoot of the BOLD signal. Furthermore, these transient effects can occur in the presence of tight coupling of cerebral blood flow and oxygen metabolism throughout the activation period. An initial test of the model against experimental measurements of flow and BOLD changes during a finger-tapping task showed good agreement.