Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID-19 and its association with composite adverse perinatal outcomes
Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID-19 and its association with composite adverse perinatal outcomes
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DOI：
10.1002/jmv.26725
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发表时间：
2020-12-23
影响因子：
12.7
通讯作者：
Sahin, Dilek
中科院分区：
文献类型：
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作者：
Erol, Seyit A.;Tanacan, Atakan;Sahin, Dilek
评估2019冠状病毒病（COVID-19）孕妇的母体血清afamin和维生素E水平，并研究其与围产期复合不良结局的相关性。这项前瞻性病例对照研究包括60名感染COVID-19的孕妇和36名年龄匹配且没有任何明确风险因素的孕妇。比较两组的人口统计学特征、实验室检查结果、afamin和维生素E水平。使用受试者操作特征（ROC）曲线来评估afamin和维生素E水平在预测围产期综合不良结局方面的关系。对COVID-19孕妇的afamin和C反应蛋白（CRP）水平进行了相关性分析。COVID-19组的产科并发症发生率较高（13.3% vs. 2.8%）（p = 0.01）。COVID-19组的Afamin水平较高，维生素E水平较低（分别为p = 0.02和p <0.001）。COVID-19组的维生素E水平在所有妊娠期都较低（分别为p < .001，p < .001和p = .004）。COVID-19组的Afamin水平在所有妊娠期均较高，但未达到统计学显著性（p > 0.05）。阿法明和维生素E的灵敏度/特异性最佳平衡的ROC曲线中的值分别为0.424 mg/l（70.6%灵敏度，44.3%特异性）和3.150 μ g/ml（76.5%灵敏度，58.2%特异性）。阿法明和CRP水平之间存在中度统计学显著正相关（r = 0.264，p = 0.009）。较高的afamin和较低的维生素E水平可能支持COVID-19发病机制中的氧化应激升高以及与复合不良围产期结局的关系。
To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID-19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case-control study consisted of 60 pregnant women with COVID-19 infection and 36 age-matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C-reactive protein (CRP) levels in pregnant women with COVID-19. The obstetric complication rate was higher in the COVID-19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID-19 group (p = .02 and p < .001, respectively). Vitamin E levels were lower in the COVID-19 group for the all trimesters (p < .001, p < .001, and p = .004, respectively). Afamin levels were higher in the COVID-19 group for the all trimesters without reaching statistical significance (p > .05). The values in the ROC curves with the best balance of sensitivity/specificity for afamin and vitamin E were 0.424 mg/l (70.6% sensitivity, 44.3% specificity) and 3.150 mu g/ml (76.5% sensitivity, 58.2% specificity), respectively. A positive moderate statistically significant correlation was found between afamin and CRP levels (r = .264, p = .009). Higher afamin and lower vitamin E levels may support the elevated oxidative stress in the etiopathogenesis of COVID-19 and the relationship with composite adverse perinatal outcomes.