Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways.

Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways.
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DOI:
10.1007/s12035-012-8240-6
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发表时间:
2012-04
影响因子:
5.1
通讯作者:
Williams, Kevin W.
Williams, Kevin W.
中科院分区:
医学2区
文献类型:
--
作者:
Sohn, Jong-Woo;Williams, Kevin W.

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弓状核(ARC)阿片黑素皮质素原(POMC)神经元是食物摄取、能量消耗和葡萄糖稳态的重要调节因子。POMC神经元整合了几个关键的代谢信号,包括神经递质和激素。POMC神经元活性的变化传递给中枢神经系统不同区域的黑素皮质素受体。本文将综述瘦素和5-羟色胺受体在调节POMC神经元活性中的作用,并提供一个不同的黑素皮质素途径调节能量和葡萄糖稳态的模型。
Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.
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