Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins
Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins
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DOI：
10.1016/s0896-6273(00)80869-7
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发表时间：
2000-01-01
期刊：
影响因子：
16.2
通讯作者：
Geppert, M
中科院分区：
文献类型：
--
作者：
Giger, RJ;Cloutier, JF;Geppert, M
神经纤毛蛋白是第3类分泌信号蛋白的受体，其中大部分可以作为有效的排斥性轴突导向线索。我们已经产生了在神经纤毛蛋白-2（Npn-2）基因座中具有靶向缺失的小鼠。许多Npn-2突变小鼠可以存活到成年，使我们能够评估Npn-2在整个神经发育过程中轴突引导事件中的作用。Npn-P是几种脑神经和脊神经的组织和成束所必需的。此外，成年突变小鼠大脑中的几个主要纤维束要么严重紊乱，要么缺失。我们的研究结果表明，Npn-2是一种选择性受体3类semaphorins在体内，Npn-1和Npn-2的发展所需的重叠，但不同的一套中枢神经系统和PNS的预测。
Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance events throughout neural development. Npn-P is required for the organization and fasciculation of several cranial nerves and spinal nerves. In addition, several major fiber tracts in the brains of adult mutant mice are either severely disorganized or missing. Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections.