Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis.
Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis.
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DOI：
10.4103/1008-682x.123673
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发表时间：
2014-05
影响因子：
2.9
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Bao JM;Song XL;Hong YQ;Zhu HL;Li C;Zhang T;Chen W;Zhao SC;Chen Q
许多研究表明FOXO 3A基因（编码叉头盒O3转录因子）与人类或男性长寿之间存在关联。然而，特定FOXO 3A多态性与长寿的关联仍然没有定论。我们对现有研究进行了荟萃分析，以澄清这些潜在的关联。进行了全面的检索，以确定FOXO 3A基因多态性和寿命的研究。通过比较次要和主要等位基因计算合并优势比（OR）和95%置信区间（CI）。共有7篇报道FOXO 3A多态性与寿命相关的文章被确定并纳入本荟萃分析。这些研究包括11项独立的研究，其中5241例病例和5724例对照来自不同种族。rs 2802292、rs 2764264、rs 13217795、rs 1935949和rs 2802288多态性与人类寿命相关（OR = 1.36，95% CI = 1.10-1.69，P = 0.005; OR = 1.20，95% CI = 1.04-1.37，P = 0.01; OR = 1.27，95% CI = 1.10-1.46，P = 0.001; OR = 1.14，95%CI = 1.01-1.27和OR = 1.24，95%CI = 1.07-1.43，P = 0.003）。按性别分层的分析表明，rs 2802292、rs 2764264和rs 13217795与男性寿命显著相关（OR = 1.54，95% CI = 1.33-1.79，P < 0.001; OR = 1.38，95% CI = 1.15-1.66，P = 0.001; OR = 1.39，95%CI = 1.15-1.67，P = 0.001），但rs 2802292、rs 2764264和rs 1935949与女性寿命无关。此外，我们的研究表明，rs 2153960，rs7762395或rs 13220810多态性与长寿之间没有关联。总之，这项荟萃分析表明，五个FOXO 3A基因多态性与长寿显著相关，其中rs 2802292和rs 2764264的影响具有男性特异性。需要进一步调查以证实这些调查结果。
Numerous studies have shown associations between the FOXO3A gene, encoding the forkhead box O3 transcription factor, and human or specifically male longevity. However, the associations of specific FOXO3A polymorphisms with longevity remain inconclusive. We performed a meta-analysis of existing studies to clarify these potential associations. A comprehensive search was conducted to identify studies of FOXO3A gene polymorphisms and longevity. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by comparing the minor and major alleles. A total of seven articles reporting associations of FOXO3A polymorphisms with longevity were identified and included in this meta-analysis. These comprised 11 independent studies with 5241 cases and 5724 controls from different ethnic groups. rs2802292, rs2764264, rs13217795, rs1935949 and rs2802288 polymorphisms were associated with human longevity (OR = 1.36, 95% CI = 1.10–1.69, P = 0.005; OR = 1.20, 95% CI = 1.04–1.37, P = 0.01; OR = 1.27, 95% CI = 1.10–1.46, P = 0.001; OR = 1.14, 95% CI = 1.01–1.27 and OR = 1.24, 95% CI = 1.07–1.43, P = 0.003, respectively). Analysis stratified by gender indicated significant associations between rs2802292, rs2764264 and rs13217795 and male longevity (OR = 1.54, 95% CI = 1.33–1.79, P < 0.001; OR = 1.38, 95% CI = 1.15–1.66, P = 0.001; and OR = 1.39, 95% CI = 1.15–1.67, P = 0.001), but rs2802292, rs2764264 and rs1935949 were not linked to female longevity. Moreover, our study showed no association between rs2153960, rs7762395 or rs13220810 polymorphisms and longevity. In conclusion, this meta-analysis indicates a significant association of five FOXO3A gene polymorphisms with longevity, with the effects of rs2802292 and rs2764264 being male-specific. Further investigations are required to confirm these findings.