White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals
White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals
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DOI：
10.1038/s41380-019-0553-7
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发表时间：
2020-04-01
影响因子：
11
通讯作者：
Hashimoto, Ryota
中科院分区：
文献类型：
--
作者：
Koshiyama, Daisuke;Fukunaga, Masaki;Hashimoto, Ryota
识别精神疾病中大脑结构的共性和差异对于理解病理生理学非常重要。最近，ENIGMA-Schizophrenia DTI工作组进行了一项大规模的荟萃分析，并报告了精神分裂症中广泛的白色物质微结构改变;然而，迄今为止还没有进行类似的交叉疾病研究。在这里，我们进行了大规模分析，比较健康对照受试者（HCS; N = 1506）与精神分裂症（N = 696）、双相情感障碍（N = 211）、自闭症谱系障碍（N = 126）或重度抑郁症（N = 398;来自12个站点的总N = 2937）患者之间的白色微结构差异。与HCS相比，我们发现精神分裂症、双相情感障碍和自闭症谱系障碍在胼胝体中具有相似的白色物质微结构差异;精神分裂症和双相情感障碍在边缘系统（如穹窿和扣带回）中具有可比性的变化。相比之下，仅在精神分裂症中观察到连接新皮质区域（例如钩束）的神经束的变化。抑郁障碍组与对照组比较差异无统计学意义。在精神分裂症和双相情感障碍之间的直接比较中，没有显著差异。精神分裂症/双相情感障碍与重性抑郁障碍在边缘系统方面存在显著差异，这与精神分裂症和双相情感障碍相对于HCS的差异相似。虽然精神分裂症和双相情感障碍可能具有相似的病理特征，但重性抑郁症的生物学特征可能与HCS的生物学特征接近。我们的研究结果提供了疾病分类学的见解，并鼓励进一步调查精神疾病的共同和独特的病理生理学。
Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophrenia; however, no similar cross-disorder study has been carried out to date. Here, we conducted mega-analyses comparing white matter microstructural differences between healthy comparison subjects (HCS; N = 1506) and patients with schizophrenia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive disorder (N = 398; total N = 2937 from 12 sites). In comparison with HCS, we found that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter microstructural differences in the body of the corpus callosum; schizophrenia and bipolar disorder featured comparable changes in the limbic system, such as the fornix and cingulum. By comparison, alterations in tracts connecting neocortical areas, such as the uncinate fasciculus, were observed only in schizophrenia. No significant difference was found in major depressive disorder. In a direct comparison between schizophrenia and bipolar disorder, there were no significant differences. Significant differences between schizophrenia/bipolar disorder and major depressive disorder were found in the limbic system, which were similar to the differences in schizophrenia and bipolar disorder relative to HCS. While schizophrenia and bipolar disorder may have similar pathological characteristics, the biological characteristics of major depressive disorder may be close to those of HCS. Our findings provide insights into nosology and encourage further investigations of shared and unique pathophysiology of psychiatric disorders.