The impact of increased body mass index on systemic lupus erythematosus -: Data from LUMINA, a multiethnic cohort
The impact of increased body mass index on systemic lupus erythematosus -: Data from LUMINA, a multiethnic cohort
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DOI：
10.1097/rhu.0b013e3180645865
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发表时间：
2007-06-01
影响因子：
3.4
通讯作者：
Alarcon, Graciela S.
中科院分区：
文献类型：
--
作者：
Chaiamnuay, Sumapa;Bertoli, Ana M.;Alarcon, Graciela S.
目的：本研究的目的是利用来自大型多民族队列Lumina的纵向数据，研究体重指数(BMI)增加对狼疮患者疾病活动性、损害累积、疲劳感、自我报告的健康相关生活质量(HRQOL)和纤维肌痛的影响。通过单变量分析，BMI增加与年龄较大、社会支持较少、无助程度较高、抑郁、更多异常疾病相关行为、较差的自我报告的HRQOL、疲劳和纤维肌痛相关，但与疾病活动或损伤增加无关。在多变量分析中，BMI与纤维肌痛独立相关，但与疾病活动、疲劳或自我报告的高QOL无关。结论：在SLE患者中，BMI增加与纤维肌痛的存在独立相关，但与疾病活动、损害累积、疲劳或自我报告的生活质量无关。优化体重值得研究，看看它是否能显著影响这种普遍存在的系统性红斑狼疮相关表现。
Objective: The aim of this study was to examine the impact of an increased body mass index (BMI) on disease activity, damage accrual, fatigue, self-reported health-related quality of life (HRQOL), and fibromyalgia in patients with lupus using longitudinal data from LUMINA, a large multiethnic cohort.Methods: SLE patients (>= 4 ACR revised criteria), = 30 kg/m(2)). An increased BMI was associated with older age, less social support, higher degree of helplessness, depression, more abnormal illness-related behaviors, poorer self-reported HRQOL, fatigue, and fibromyalgia, but not with disease activity or damage accrual by univariable analyses. In multivariable analyses, BMI was independently associated with fibromyalgia but not with disease activity, fatigue, or self-reported HRQOL.Conclusions: An increased BMI is independently associated with presence of fibromyalgia but not with disease activity, damage accrual, fatigue or self-reported quality of life in patients with SLE. Optimizing weight merits investigation to see if it can significantly impact this pervasive SLE-associated manifestation.