Adipose Tissue Infiltration of Skeletal Muscle in Children with Cerebral Palsy
Adipose Tissue Infiltration of Skeletal Muscle in Children with Cerebral Palsy
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DOI：
10.1016/j.jpeds.2008.10.046
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发表时间：
2009-05-01
影响因子：
5.1
通讯作者：
Modlesky, Christopher M.
中科院分区：
文献类型：
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作者：
Johnson, David L.;Miller, Freeman;Modlesky, Christopher M.
目的探讨四肢瘫痪(QCP)患儿骨骼肌脂肪组织(AT)是否高于正常发育儿童(12/组和5~14岁)。研究设计采用磁共振成像技术测量大腿中段AT和肌肉的横截面积。结果QCP患儿大腿中段肌肉ATCSA较对照组增加2.3倍，肌肉CSA降低51%。校正大腿中段肌间、筋膜下和皮下的ATCSA，QCP患儿的CSA较高(均P
Objective To determine whether children with quadriplegic cerebral palsy (QCP) have a greater adipose tissue (AT) infiltration of skeletal muscle than typically developing children (12/group and 5-14 years).Study design Cross-sectional area (CSA) of AT and muscle in the midthigh were assessed with magnetic resonance imaging. Physical activity was assessed with an activity monitor.Results Children with QCP had 2.3-fold higher intermuscular AT CSA and 51% lower muscle CSA in the midthigh than control subjects. Midthigh intermuscular, subfascial, and subcutaneous AT CSA adjusted for midthigh muscle CSA were higher in children with QCP (all P