Delayed hypometabolism induced by bilateral ischemia in the gerbil: regional metabolic thresholds.
Delayed hypometabolism induced by bilateral ischemia in the gerbil: regional metabolic thresholds.
复制标题
沙鼠双侧缺血引起的迟发性代谢低下：区域代谢阈值。
DOI：
10.1007/bf00999538
复制
发表时间：
1988
影响因子：
3.6
通讯作者：
Lust,WD
中科院分区：
文献类型：
--
作者：
Mrsulja,BB;Ueki,Y;Lust,WD
沙土鼠颈总动脉闭塞5分钟，代谢率通过测量再灌注4天时大脑皮层、海马和纹状体中高能磷酸盐当量的损失来估计。再灌注4天时的代谢物值与对照组没有差异，但海马中的糖原显着升高。再流4天时通过“闭盒”方法测定的代谢率，双侧缺血5分钟后，所有三个区域的代谢率均下降了50%以上。在再流4天引起低代谢反应所需的缺血时间分别为纹状体、海马和皮质2、3和4分钟。有人建议，延迟postischemic代谢低下可能是一个自适应过程的一个组成部分，抵消，在不同程度上，缺血的有害影响取决于检查的区域。
The common carotid arteries were occluded in gerbils for 5 min and the metabolic rate was estimated by measuring the loss of high-energy phosphate equivalents at 4 days of reperfusion in the cerebral cortex, hippocampus, and striatum. Metabolites values at 4 days of reperfusion were not different from those of controls with the exception of glycogen, which was significantly elevated in the hippocampus. The metabolic rate, as determined by the “closed-box” method at 4 days of reflow, was decreased by more than 50% in all three regions after 5 min of bilateral ischemia. The ischemie time necessary to elicit the hypometabolic response at 4 days of reflow was 2, 3, and 4 min for the striatum, hippocampus, and cortex, respectively. It is suggested that delayed postischemic hypometabolism may be a component of an adaptive process which counteracts, to varying degrees, the deleterious effects of ischemia depending on the region examined.