Multiscale and Extended Retrieval of Associative Memory Structures in a Cortical Model of Local-Global Inhibition Balance
Multiscale and Extended Retrieval of Associative Memory Structures in a Cortical Model of Local-Global Inhibition Balance
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DOI：
10.1523/eneuro.0023-22.2022
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发表时间：
2021-12
期刊：
影响因子：
3.4
通讯作者：
Thomas F Burns;Tatsuya Haga;T. Fukai
中科院分区：
文献类型：
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作者：
Thomas F Burns;Tatsuya Haga;T. Fukai
摘要抑制性神经元具有多种形式和功能。这种多样性对记忆功能的影响尚不完全清楚。以往的研究表明，在联想记忆网络功能的局部和全局连接区分抑制重新调整兴奋性组件的检索水平。然而，这些研究缺乏生物学细节，如神经元类型（兴奋性和抑制性）之间的区别，不切实际的连接模式和非稀疏组装。在这项研究中，我们提出了一个基于速率的皮层模型，神经元区分（兴奋性，局部抑制性，或全球抑制性），连接更现实，记忆项目对应于稀疏的兴奋性组件。我们使用这个模型来研究局部-全局抑制平衡如何改变联想记忆结构中的记忆提取，包括自然结构和人工结构。实验研究已经报道了抑制性神经元及其亚型对特定刺激的独特反应，并且可以形成复杂的联合兴奋-抑制组装。我们的模型表明，这样的联合大会，以及两个抑制亚群之间的分布和再平衡的整体抑制，一个连接到兴奋性组件本地和其他连接全球，可以翻两番的范围内检索相关的记忆。我们确定了一个可能的功能作用，局部-全局抑制平衡，在选择或偏好的关系的背景下，允许和保持更广泛的记忆项目时，局部抑制占主导地位，反之，巩固和加强一个较小范围的记忆项目时，全球抑制占主导地位。这个模型，虽然仍然是理论上的，因此突出了一个潜在的生物学上合理的和行为上有用的功能，抑制多样性的记忆。
Abstract Inhibitory neurons take on many forms and functions. How this diversity contributes to memory function is not completely known. Previous formal studies indicate inhibition differentiated by local and global connectivity in associative memory networks functions to rescale the level of retrieval of excitatory assemblies. However, such studies lack biological details such as a distinction between types of neurons (excitatory and inhibitory), unrealistic connection schemas, and nonsparse assemblies. In this study, we present a rate-based cortical model where neurons are distinguished (as excitatory, local inhibitory, or global inhibitory), connected more realistically, and where memory items correspond to sparse excitatory assemblies. We use this model to study how local-global inhibition balance can alter memory retrieval in associative memory structures, including naturalistic and artificial structures. Experimental studies have reported inhibitory neurons and their subtypes uniquely respond to specific stimuli and can form sophisticated, joint excitatory-inhibitory assemblies. Our model suggests such joint assemblies, as well as a distribution and rebalancing of overall inhibition between two inhibitory subpopulations, one connected to excitatory assemblies locally and the other connected globally, can quadruple the range of retrieval across related memories. We identify a possible functional role for local-global inhibitory balance to, in the context of choice or preference of relationships, permit and maintain a broader range of memory items when local inhibition is dominant and conversely consolidate and strengthen a smaller range of memory items when global inhibition is dominant. This model, while still theoretical, therefore highlights a potentially biologically-plausible and behaviorally-useful function of inhibitory diversity in memory.