Interactions between toxic and essential trace metals in cattle from a region with low levels of pollution
Interactions between toxic and essential trace metals in cattle from a region with low levels of pollution
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DOI：
10.1007/s00244-001-0012-7
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发表时间：
2002-02-01
影响因子：
4
通讯作者：
Shore, RF
中科院分区：
文献类型：
--
作者：
Alonso, ML;Benedito, JL;Shore, RF
关于污染物金属和类金属对牲畜影响的研究主要集中在接触水平相对较高的动物上。低度环境污染在农业用地上更为常见，其影响在很大程度上尚不清楚。本研究的主要目的是研究低水平环境污染对加利西亚（西班牙西北部）农村和相对未受污染地区的牛微量金属代谢的影响。对来自加利西亚各地的 494 头牛的组织（肝脏、肾脏和肌肉）和血液中有毒物质（镉、铅和砷）与必需微量元素（铜和锌）之间的相关性进行了评估。镉是对铜和锌稳态影响最大的有毒元素。肾脏镉和锌残留量呈显着正相关，肾脏镉和铜残留量呈显着负相关。这些相互作用可能是镉对金属硫蛋白合成产生影响的结果。铅和锌在肾脏中呈正相关，尽管这种相互作用的机制尚不确定。肝脏中砷和铜的浓度彼此密切相关，这可能表明加利西亚富铜地区动物体内的高铜水平会干扰其砷的排泄。必需金属铜和锌在犊牛中也存在显着相关性，但在奶牛中则没有。
Studies on the impacts of pollutant metals and metalloids on livestock have largely focused on animals with relatively high levels of exposure. The impact of low-level environmental contamination, which is more common on agricultural land, is largely unknown. The principal aim of the present study was to examine the effects of low-level environmental contamination on trace metal metabolism in cattle from the rural and relatively uncontaminated region of Galicia (NW Spain). Correlations between toxic (cadmium, lead, and arsenic) and essential trace elements (copper and zinc) were evaluated in the tissues (liver, kidney, and muscle) and blood of 494 cattle from throughout Galicia. Cadmium was the toxic element that had the greatest influence on copper and zinc homeostasis. There was a significant positive association between renal cadmium and zinc residues and a significant negative correlation between kidney cadmium and copper. These interactions are likely to be the result of cadmium-induced effects on metallothionein synthesis. Lead and zinc were positively associated in the kidney, although the mechanism of this interaction is uncertain. Arsenic and copper concentrations were strongly correlated with each other in the liver and may indicate that the high copper levels in animals from copper-rich areas in Galicia interfere with their arsenic excretion. The essential metals copper and zinc were also significantly associated with each other in calves but not in cows.