CPG ISLANDS AND GENES
CPG ISLANDS AND GENES
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DOI：
10.1016/0959-437x(95)80044-1
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发表时间：
1995-06-01
影响因子：
4
通讯作者：
BIRD, AP
中科院分区：
文献类型：
--
作者：
CROSS, SH;BIRD, AP
在人类基因组中估计有45000个CpG岛，绝大多数位于基因的5'端，它们的鉴定和克隆被证明对发现和分离基因非常有用。最近的工作揭示了CpG岛的染色体分布和起源。已经明确表明，CpG岛集中在R带染色体区域，并且完整的转录因子结合位点是其维持所必需的。CpG岛甲基化和相关基因失活的情况已经报道，这可能在衰老、肿瘤发生和印记中很重要。
Of the estimated 45 000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands. It has been shown unequivocally that CpG islands are concentrated in the R band chromosomal regions and that intact transcription factor binding sites are required for their maintenance. Cases of methylation of CpG islands and inactivation of the associated genes have been reported which may be important in ageing, tumorigenesis and imprinting.