Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel
Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel
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Synaptobrevin-2 促进心房 SK2 通道的运输和功能
DOI：
10.1007/s11427-017-9139-7
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Xiaoqiu Tan
中科院分区：
文献类型：
--
作者：
Tao Li;Xuehui Fan;Yiyan Yu;Linlin Chen;Wenjun Huang;Yan Yang;Jimin Cao;Xiaorong Zeng;Xiaoqiu Tan
Small conductance Ca2+-activated potassium (SK) channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2+ levels and membrane potential (Adelman et al., 2012). Xu et al. first identified SK channels in the heart and found that SK channels, particularly the SK2 channel, are preferentially expressed in human and mouse atrial myocytes but not in ventricular myocytes (Xu et al., 2003). This suggests that the SK channel modulates the repolarization of atrial action potentials and may be an ideal therapeutic target for treating atrial arrhythmias, including atrial fibrillation (AF) without interfering with ventricular function. These results were further supported by the finding that either overexpression or knockout of SK channels increased the risk of atrial arrhythmias, including AF.Synthesized ion channel proteins must be transferred to the cell membrane to function. Therefore, SK channel trafficking is important for channel function to maintain normal atrial electrophysiology. Changes in atrial electric activity may affect channel trafficking; Ozgen et al. showed that atrial rapid pacing accelerated trafficking of the SK2 channel protein to-
