Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention
Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention
复制标题
DOI：
10.1016/s0006-8993(00)02495-1
复制
发表时间：
2000-07-28
期刊：
影响因子：
2.9
通讯作者：
Morley, JE
中科院分区：
文献类型：
--
作者：
Farr, SA;Banks, WA;Morley, JE
海马体被广泛认为在学习和记忆中发挥着重要作用。海马体的损伤会扰乱空间导航学习和记忆，向海马体注射药物会影响空间导航和非空间任务。在当前的研究中，我们测试了双侧电解损伤和海马可逆失活对 T 迷宫足部电击避免条件的获得和保留的影响。电解损伤，破坏了 31+/-0.04% 的海马体。避免 T 迷宫足部电击的采集和保留显着受损。病变组和对照组之间在避免电击、旷场活动或足部电击敏感性方面没有发现差异。在训练前立即使用利多卡因暂时灭活海马会扰乱避免 T 迷宫足部电击的获取和保留。在记忆测试之前进行的暂时海马失活以及在首次回避训练的小鼠中进行训练后失活对记忆没有影响。然而，“训练不足”的小鼠（如果用盐水处理，则有足够的试验在 1 周后记住，但不允许做出回避反应）的训练后暂时失活会损害记忆力。目前的研究结果表明，海马体在厌恶 T 迷宫范式中的学习和记忆处理中发挥着重要作用。 (C) 2000 Elsevier Science B.V. 保留所有权利。
The hippocampus is widely recognized as playing an important role in learning and memory. Lesions of the hippocampus can disrupt spatial navigational learning and memory and injection of drugs into the hippocampus can affect both spatial navigational and nonspatial tasks. In the current studies we tested the effects of bilateral of electrolytic lesions and reversible inactivation of the hippocampus on acquisition and retention of T-maze footshock avoidance conditioning. Electrolytic lesions, which destroyed 31+/-0.04% of the hippocampus. significantly impaired acquisition and retention for T-maze footshock avoidance. No differences were found in motivation to avoid shock, open field activity, or foot shock sensitivity between lesion and control groups. Temporary inactivation of the hippocampus with lidocaine administered immediately before training disrupted acquisition and retention for T-maze footshock avoidance. Temporary hippocampal inactivation performed just prior to retention testing and post-training inactivation in mice trained to first avoidance had no effect on retention. However, temporary post-training inactivation in 'undertrained' (enough trials to remember 1 week later if treated with saline, but not allowed to make the avoidance response) mice impaired retention. The current findings indicate that the hippocampus plays an important role in learning and memory processing in the aversive T-maze paradigm. (C) 2000 Elsevier Science B.V. All rights reserved.