Classification of image artefacts in optical coherence tomography angiography of the choroid in macular diseases
Classification of image artefacts in optical coherence tomography angiography of the choroid in macular diseases
复制标题
DOI：
10.1111/ceo.12683
复制
发表时间：
2016-07-01
影响因子：
4
通讯作者：
Bukowska, Danuta M.
中科院分区：
文献类型：
--
作者：
Chen, Fred K.;Viljoen, Rian D.;Bukowska, Danuta M.
为评价和分类黄斑疾病患者脉络膜光学相干断层扫描(OCT)血管成像中的伪影。设计回顾观察研究。研究对象5例老年性黄斑变性患者，3例中心性浆液性视网膜病变，1例息肉状脉络膜血管病变和1例多发性消失性白点综合征。方法回顾OCTA和OCT反射率(OCTR)图及其荧光血管造影和吲哚青绿血管造影。对60幅OCTA图像(20层外视网膜、20层Sattler层和20层Haller层)进行图像伪影分级。主要观察指标：OCTA伪影及其与OCTR图、血管造影和OCT B超的相关性。结果OCTA伪影(频率)分为：(1)运动(70-100%)，(2)条纹消失(100%)，(3)去相关投影(0-20%)，(4)掩蔽和去掩蔽(50-65%)和(5)基质去相关信号(100%)。OCTA的运动伪影的特点是在OCTR图上不明显的水平暗线或条带。由于血流速度快，边缘冲洗会在脉络膜血管内产生信号空洞。脉络膜OCTA图像中可见脱离视网膜血管的投射和Bruch膜上方的脉络膜新生血管。遮盖和揭开伪影发生在色素上皮脱落和萎缩区域。结论我们建立的脉络膜OCTA伪影分类系统为临床解释建立了一个通用术语。这对于增进我们对OCTA采购原则的理解很重要，也是阅读中心的基准。
BackgroundTo evaluate and classify image artefacts in optical coherence tomography (OCT) angiography (OCTA) of the choroid in a group of patients with macular diseases.DesignRetrospective observational study.ParticipantsFive patients with age-related macular degeneration, three with central serous retinopathy, one with polypoidal choroidal vasculopathy and one with multiple evanescent white dot syndrome.MethodsOCTA and OCT reflectivity (OCTR) maps were reviewed along with their fluorescein angiography and indocyanine green angiography. Sixty OCTA images (20 outer retina, 20 Sattler and 20 Haller layers) were graded for image artefacts by two examiners independently.Main Outcome MeasuresOCTA artefacts and their correlation with OCTR maps, angiography and OCT B-scans.ResultsArtefacts (frequency) were classified into (i) motion (70-100%), (ii) fringe washout (100%), (iii) decorrelation projection (0-20%), (iv) masking and unmasking (50-65%) and (v) stromal decorrelation signal (100%). Motion artefact in OCTA is characterized by horizontal dark lines or bands not apparent on OCTR map. Fringe washout creates signal void within choroidal vessels because of fast blood flow. Decorrelation projection from retinal vasculature and choroidal new vessels above the Bruch's membrane are seen within the choroidal OCTA image. Masking and unmasking artefacts occur in regions of pigment epithelial detachment and atrophy. Decorrelation signals can also be seen in the choroidal stroma.ConclusionsOur classification system of artefact in choroidal OCTA establishes a common terminology for clinical interpretation. This is important in enhancing our understanding of the principles of OCTA acquisition, and it also serves as a bench mark for reading centres.